ArticleFrontiers in neuroscience2019
High-Density Electrical Recording and Impedance Imaging With a Multi-Modal CMOS Multi-Electrode Array Chip.
Article in Frontiers in neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed.
- Microelectrode Arrays Technology for Brain-on-a-Chip Applications.Biosensors · 2026Review
- Customizable Fabrication of 2D and Conformal Multielectrode Arrays for 3D Printed Organotypic Bioelectronic Interfaces.Advanced healthcare materials · 2026Article
- UV Laser-Induced Carbon Microelectrode Arrays for Neuronal Recordings.Advanced healthcare materials · 2025Article
- Advances in large-scale electrophysiology with high-density microelectrode arrays.Lab on a chip · 2025Review
- Decoding Pain: Next-Generation In Vitro Systems for Mechanistic Insights and Drug Discovery.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Review
- Adoption of microfluidic MEA technology for electrophysiology of 3D neuronal networks exposed to suborbital conditions.NPJ microgravity · 2025Article
- Electrode- and Label-Free Assessment of Electrophysiological Firing Rates through Cytochrome C Monitoring via Raman Spectroscopy.ACS sensors · 2025Article
- Impedance mapping with high-density microelectrode array chips reveals dynamic heterogeneity of in vitro epithelial barriers.Scientific reports · 2025Article
- From microelectrode arrays to all-optical and multimodal neural interfaces: emerging platforms for spatiotemporal interrogation ofFrontiers in synaptic neuroscience · 2025Review
- The Role of Human-Induced Pluripotent Stem Cells in Studying Cardiac Channelopathies.International journal of molecular sciences · 2024Review
- Novel Multiparametric Bioelectronic Measurement System for Monitoring Virus-Induced Alterations in Functional Neuronal Networks.Biosensors · 2024Article
- Numerical investigation of a graphene-on-semiconductor device for optical monitoring of cell electrophysiology.iScience · 2024Article
- Flexible high-density microelectrode arrays for closed-loop brain-machine interfaces: a review.Frontiers in neuroscience · 2024Review
- Organoid intelligence for developmental neurotoxicity testing.Frontiers in cellular neuroscience · 2024Article
- Internet-Connected Cortical Organoids for Project-Based Stem Cell and Neuroscience Education.eNeuro · 2023Article
- Using Human-Induced Pluripotent Stem Cell Derived Neurons on Microelectrode Arrays to Model Neurological Disease: A Review.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Review
- Internet-connected cortical organoids for project-based stem cell and neuroscience education.bioRxiv : the preprint server for biology · 2023Article
- A CMOS-based highly scalable flexible neural electrode interface.Science advances · 2023Article
- Stimulation-mediated reverse engineering of silent neural networks.Journal of neurophysiology · 2023Article
- Impedance Imaging of Cells and Tissues: Design and Applications.BME frontiers · 2022Article
Corrections and comments
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Authors and funding
11 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Multi-electrode arrays, both active or passive, emerged as ideal technologies to unveil intricated electrophysiological dynamics of cells and tissues. Active MEAs, designed using complementary metal oxide semiconductor technology (CMOS), stand over passive devices thanks to the possibility of achieving single-cell resolution, the reduced electrode size, the reduced crosstalk and the higher functionality and portability. Nevertheless, most of the reported CMOS MEA systems mainly rely on a single operational modality, which strongly hampers the applicability range of a single device. This can be a limiting factor considering that most biological and electrophysiological dynamics are often based on the synergy of multiple and complex mechanisms acting from different angles on the same phenomena. Here, we designed a CMOS MEA chip with 16,384 titanium nitride electrodes, 6 independent operational modalities and 1,024 parallel recording channels for neuro-electrophysiological studies. Sixteen independent active areas are patterned on the chip surface forming a 4 × 4 matrix, each one including 1,024 electrodes. Electrodes of four different sizes are present on the chip surface, ranging from 2.5 × 3.5 μm
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