ReviewFrontiers in neuroscience2019
Measures of CNS-Autonomic Interaction and Responsiveness in Disorder of Consciousness.
Review in Frontiers in neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 39 citations in OpenAlex.
- The autonomic response following taVNS predicts changes in level of consciousness in DoC patients.Scientific reports · 2025Trial
- The Mind From Within: Visceral Roots of Human Cognition.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Long-term HRV metrics may assist in differentiating between prolonged disorders of consciousness and emergence from minimally conscious state : a cross-sectional study.Acta neurologica Belgica · 2026Article
- Respiratory Variability in Disorders of Consciousness: Relationship and Clinical Applications.CNS neuroscience & therapeutics · 2026Article
- The brain and heart-axis in neurodegeneration and cardiovascular disease.Journal of neural transmission (Vienna, Austria : 1996) · 2026Review
- Autonomic heart rate variability trends predict outcome in disorders of consciousness.Scientific reports · 2025Article
- Central Thalamic Deep Brain Stimulation Modulates Autonomic Nervous System Responsiveness in Disorders of Consciousness.CNS neuroscience & therapeutics · 2025Article
- Heart rate variability responses to personalized and non-personalized affective videos. A study on healthy subjects and patients with disorders of consciousness.Frontiers in psychology · 2025Article
- Uncovering sympathetic nervous system dysfunction in disorders of consciousness via heart rate variability during head-up tilt test.Physiological reports · 2024Article
- Synchronous monitoring of brain-heart electrophysiology using heart rate variability coupled with rapid quantitative electroencephalography in orthostatic hypotension patients with α-synucleinopathies: Rapid prediction of orthostatic hypotension and preliminary exploration of brain stimulation therapy.CNS neuroscience & therapeutics · 2024Article
- Central autonomic network and early prognosis in patients with disorders of consciousness.Scientific reports · 2024Article
- Article
- Can Respiration Complexity Help the Diagnosis of Disorders of Consciousness in Rehabilitation?Diagnostics (Basel, Switzerland) · 2023Article
- Depression as a cardiovascular disorder: central-autonomic network, brain-heart axis, and vagal perspectives of low mood.Frontiers in network physiology · 2023Article
- Inhibitory Control and Brain-Heart Interaction: An HRV-EEG Study.Brain sciences · 2022Article
- Gastrointestinal and Autonomic Symptoms-How to Improve the Diagnostic Process in Panayiotopoulos Syndrome?Children (Basel, Switzerland) · 2022Review
- Brain-heart interactions in the neurobiology of consciousness.Current research in neurobiology · 2022Review
- Contrasting Associations Between Heart Rate Variability and Brainstem-Limbic Connectivity in Posttraumatic Stress Disorder and Its Dissociative Subtype: A Pilot Study.Frontiers in behavioral neuroscience · 2022Article
- A Framework for Revisiting Brain Death: Evaluating Awareness and Attitudes Toward the Neuroscientific and Ethical Debate Around the American Academy of Neurology Brain Death Criteria.Journal of intensive care medicine · 2021Article
- Positive effects of music therapist's selected auditory stimulation on the autonomic nervous system of patients with disorder of consciousness: a randomized controlled trial.Neural regeneration research · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neuroimaging studies have demonstrated functional interactions between autonomic (ANS) and brain (CNS) structures involved in higher brain functions, including attention and conscious processes. These interactions have been described by the Central Autonomic Network (CAN), a concept model based on the brain-heart two-way integrated interaction. Heart rate variability (HRV) measures proved reliable as non-invasive descriptors of the ANS-CNS function setup and are thought to reflect higher brain functions. Autonomic function, ANS-mediated responsiveness and the ANS-CNS interaction qualify as possible independent indicators for clinical functional assessment and prognosis in Disorders of Consciousness (DoC). HRV has proved helpful to investigate residual responsiveness in DoC and predict clinical recovery. Variability due to internal (e.g., homeostatic and circadian processes) and environmental factors remains a key independent variable and systematic research with this regard is warranted. The interest in bidirectional ANS-CNS interactions in a variety of physiopathological conditions is growing, however, these interactions have not been extensively investigated in DoC. In this brief review we illustrate the potentiality of brain-heart investigation by means of HRV analysis in assessing patients with DoC. The authors' opinion is that this easy, inexpensive and non-invasive approach may provide useful information in the clinical assessment of this challenging patient population.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.