Trial reportPhysiological reports2019
Impaired microvascular reactivity after eccentric muscle contractions is not restored by acute ingestion of antioxidants or dietary nitrate.
Trial report in Physiological reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effectiveness of Nitrate Intake on Recovery from Exercise-Related Fatigue: A Systematic Review.International journal of environmental research and public health · 2022Pooled it
- The effects of simultaneous isometric and eccentric- or concentric-biased exercise on cardiovascular and muscular health of young individuals.European journal of applied physiology · 2026Trial
- The effect of acute beetroot juice consumption prior to climbing on lower-body isokinetic and isometric strength, aerobic power, and muscle soreness among mountain climbers.Journal of the International Society of Sports Nutrition · 2025Trial
- Trial
- Effects of home-based leg heat therapy on walking performance in patients with symptomatic peripheral artery disease: a pilot randomized trial.Journal of applied physiology (Bethesda, Md. : 1985) · 2022Trial
- Impaired microvascular reactivity after eccentric muscle contractions is not restored by acute ingestion of antioxidants or dietary nitrate.Physiological reports · 2019Trial
- Altered Skeletal Muscle Phosphate Metabolism After Muscle Damage Is Associated With Elevated Effort Perception During Exercise in Humans.Scandinavian journal of medicine & science in sports · 2026Article
- The effect of beetroot juice (BRJ) supplementation on exercise-induced muscle damage (EIMD): a systematic review and dose-response meta-analysis of randomized controlled trials.Annals of medicine and surgery (2012) · 2026Article
- Examination of post-exercise microvascular reactivity in healthy adults.European journal of applied physiology · 2026Article
- Development and feasibility testing of a new device for home-based leg heat therapy in patients with lower extremity peripheral artery disease.Journal of vascular surgery cases and innovative techniques · 2025Article
- Muscle energetics and the cardiovascular response to isometric exercise and post-exercise circulatory occlusion following exercise-induced muscle damage: insights from multiparametric MRI.Frontiers in physiology · 2025Article
- Consuming Beetroot Juice Improves Slalom Performance and Reduces Muscle Soreness in Alpine Skiers under Hypoxic Conditions.Current developments in nutrition · 2024Article
- Contrast-free ultrasound imaging for blood flow assessment of the lower limb in patients with peripheral arterial disease: a feasibility study.Scientific reports · 2023Article
- Nutritional Compounds to Improve Post-Exercise Recovery.Nutrients · 2022Review
- Progress of Clinical Evaluation for Vascular Aging in Humans.Journal of translational internal medicine · 2021Review
- Effect of heat pre-conditioning on recovery following exercise-induced muscle damage.Current research in physiology · 2021Article
- Local Heat Therapy to Accelerate Recovery After Exercise-Induced Muscle Damage.Exercise and sport sciences reviews · 2020Review
- Quantitative and Dynamic MRI Measures of Peripheral Vascular Function.Frontiers in physiology · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Unaccustomed eccentric exercise leads to impaired microvascular function but the underlying mechanism is unknown. In this study, we evaluated the role of oxidative stress and of nitric oxide (NO) bioavailability. Thirty young men and women performed eccentric contractions of the tibialis anterior (TA) muscle (ECC), with the contralateral leg serving as nonexercising control (CON). Participants were randomized into three groups ingesting an antioxidant cocktail (AO), beetroot juice (BR) or placebo 46 h postexercise. At baseline and 48 h postexercise, hyperemic responses to brief muscle contractions and 5 min of cuff occlusion were assessed bilaterally in the TA muscles using blood oxygen level dependent (BOLD) magnetic resonance imaging. Eccentric contractions resulted in delayed time-to-peak (~22%; P < 0.001), blunted peak (~21%; P < 0.001) and prolonged time-to-half relaxation (~12%, P < 0.001) in the BOLD response to brief contractions, with no effects of AO or BR, and no changes in CON. Postocclusive time-to-peak was also delayed (~54%; P < 0.001) in ECC, with no effects of AO or BR, and no changes in CON. Impaired microvascular reactivity after eccentric contractions is confined to the exercised tissue, and is not restored with acute ingestion of AO or BR. Impairments in microvascular reactivity after unaccustomed eccentric contractions may result from structural changes within the microvasculature that can diminish muscle blood flow regulation during intermittent activities requiring prompt adjustments in oxygen delivery.
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