Evidence map›Paper›PMID 31292966›Full record

ArticleJournal of periodontal research2020

Association of P2RX7 functional variants with localized aggressive periodontitis.

Theodore H Harris, Margaret R Wallace, Hong Huang, Hua Li, Azeem Mohiuddeen, Yan Gong, Theodora Kompotiati, Peter Harrison, Ikramuddin Aukhil, Luciana M Shaddox

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of periodontal research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Purinergic Signaling in Oral Tissues.International journal of molecular sciences · 2022
    Review
  7. Lactobacilli Attenuate the Effect ofFrontiers in microbiology · 2022
    Article
  8. Review
  9. Article
  10. Associations ofJDR clinical and translational research · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Theodore H HarrisDepartment of Periodontology, University of Florida College of Dentistry, Gainesville, Florida, USA.ORCID https://orcid.org/0000-0001-6589-9764
Margaret R WallaceDepartment of Molecular Genetics and Microbiology, University of Florida College of Medicine, Gainesville, Florida, USA.
Hong HuangDepartment of Periodontology, University of Florida College of Dentistry, Gainesville, Florida, USA.
Hua LiDepartment of Molecular Genetics and Microbiology, University of Florida College of Medicine, Gainesville, Florida, USA.
Azeem MohiuddeenDepartment of Periodontology, University of Florida College of Dentistry, Gainesville, Florida, USA.
Yan GongDepartment of Pharmacotherapy and Translational Research and Center for Pharmacogenomics, University of Florida College of Pharmacy, Gainesville, Florida, USA.
Theodora KompotiatiDepartment of Periodontology, University of Florida College of Dentistry, Gainesville, Florida, USA.
Peter HarrisonDivision of Restorative Dentistry & Periodontology, Dublin Dental University Hospital, Trinity College, Dublin, Ireland.
Ikramuddin AukhilDepartment of Periodontology, University of Florida College of Dentistry, Gainesville, Florida, USA.
Luciana M ShaddoxDivision of Periodontology, Department of Oral Health Practice, University of Kentucky College of Dentistry, Lexington, Kentucky, USA.ORCID https://orcid.org/0000-0003-0948-1667
University of Florida · USTrinity College Dublin · IEUniversity of Kentucky · US

Funding

Mechanisms and Treatment Response of Aggressive Periodontitis in ChildrenR01DE019456 · NIDCR · UNIVERSITY OF FLORIDA · PI AUKHIL, IKRAMUDDIN, SHADDOX, LUCIANA MACCHION · 2009 to 2018
$5.6M
NIDCR NIH HHS R01 DE019456NIDCR NIH HHS R01DE019456
6 · The paper itself

Abstract

objectiveThe purpose of this study was to investigate involvement of the P2X7 receptor in the rare condition, localized aggressive periodontitis. MATERIAL AND

methodsPeripheral blood from 220 African Americans (103 with localized aggressive periodontitis and 117 healthy unrelated controls) was stimulated with lipopolysaccharide from E coli and Porphyromonas gingivalis. P2RX7 single nucleotide polymorphisms rs208294 (H155Y), rs1718119 (T348A), rs2230911 (T357S) and rs3751143 (E496A) were genotyped in 103 localized aggressive periodontitis patients and 117 healthy unrelated subjects. We examined genetic association between four P2RX7 single nucleotide polymorphisms and localized aggressive periodontitis, and tested for correlations between the single nucleotide polymorphisms and inflammatory response to lipopolysaccharide in blood samples from these patients.

resultsA significant association with localized aggressive periodontitis was observed with rs1718119 A (Thr) allele (P = 0.0063, odds ratio = 1.904) and with a haplotype containing this allele (P = 0.0075). Additionally, significant correlations with these data were found: the rs1718119 G allele correlated with greater production of IL-6, IL-2 and GM-CSF; the C (His) allele of rs208294 correlated with lower levels of IL-12p40; and the C (Thr) allele of rs2230911 correlated with greater levels of G-CSF.

conclusionThe data from these analyses support a possible biological relationship between P2RX7 genetic variants and inflammatory response in localized aggressive periodontitis patients.

Indexed as

Polymorphism, Single NucleotideAdolescentAggressive PeriodontitisBlack or African AmericanCase-Control StudiesChildCytokinesFemaleGenetic Association StudiesHaplotypesHumansMaleReceptors, Purinergic P2X7Young AdultCytokinesP2RX7 protein, humanReceptors, Purinergic P2X7

Identifiers

PMID31292966
PMCPMC8018522
OpenAlexW2956445788

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.