Evidence map›Paper›PMID 31292914›Full record

ArticleMolecular imaging and biology2020

Targeting VPAC1 Receptors for Imaging Glioblastoma.

Sushil K Tripathi, Rhonda Kean, Emily Bongiorno, Douglas C Hooper, Yuan-Yuan Jin, Eric Wickstrom, Peter A McCue, Mathew L Thakur

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular imaging and biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Glioma and Peptidergic Systems: Oncogenic and Anticancer Peptides.International journal of molecular sciences · 2024
    Review
  2. Review
  3. Cell-Based Tracers as Trojan Horses for Image-Guided Surgery.International journal of molecular sciences · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Sushil K TripathiDepartment of Radiology, Thomas Jefferson University, Philadelphia, PA, USA.
Rhonda KeanDepartment of Cancer Biology, Thomas Jefferson University, Philadelphia, PA, USA.
Emily BongiornoDepartment of Cancer Biology, Thomas Jefferson University, Philadelphia, PA, USA.
Douglas C HooperDepartment of Cancer Biology, Thomas Jefferson University, Philadelphia, PA, USA.
Yuan-Yuan JinBound Therapeutics LLC, Philadelphia, PA, USA.
Eric WickstromDepartment of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, PA, USA.
Peter A McCueDepartment of Pathology, Thomas Jefferson University, Philadelphia, PA, USA.
Mathew L ThakurDepartment of Radiology, Thomas Jefferson University, Philadelphia, PA, USA. Mathew.Thakur@jefferson.edu.
Thomas Jefferson University · USSidney Kimmel Cancer Center · US

Funding

NIH HHS 1S10OD012406NIH HHS RO1CA157372NIH HHS S10RR23709
6 · The paper itself

Abstract

purposeScintigraphic imaging of malignant glioblastoma (MG) continues to be challenging. We hypothesized that VPAC1 cell surface receptors can be targeted for positron emission tomography (PET) imaging of orthotopically implanted MG in a mouse model, using a VPAC1-specific peptide [ PROCEDURES: The expression of VPAC1 in mouse GL261 and human U87 glioma cell lines was determined by western blot. The ability of [

resultsWestern blots showed a strong signal for VPAC1 on both cell lines. [

conclusionTargeting VPAC1 receptors using [

Indexed as

Positron Emission Tomography Computed TomographyAnimalsBrainBrain NeoplasmsCell Line, TumorCopper RadioisotopesFluorodeoxyglucose F18GlioblastomaHumansMiceMice, Inbred C57BLMice, KnockoutNeoplasm TransplantationPeptidesRadiopharmaceuticalsReceptors, Vasoactive Intestinal Polypeptide, Type ICopper RadioisotopesFluorodeoxyglucose F18PeptidesRadiopharmaceuticalsReceptors, Vasoactive Intestinal Polypeptide, Type IVIPR1 protein, human[64Cu]TP3805GlioblastomaPET imagingVPAC1

Identifiers

PMID31292914
OpenAlexW2956765372

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.