ArticleMetabolic brain disease2019
A single nucleotide polymorphism within Ninjurin 2 is associated with risk of multiple sclerosis.
Article in Metabolic brain disease, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 16 citations in OpenAlex.
- Nerve injury-induced protein 2 preserves lysosomal membrane integrity to suppress ferroptosis.eLife · 2026Article
- Nerve Injury-Induced Protein 2 preserves lysosomal membrane integrity to suppress ferroptosis.bioRxiv : the preprint server for biology · 2026Article
- Influence of Citrobacter freundii on NINJ2 Expression and Oxaliplatin Resistance in Colorectal Cancer.Cancer medicine · 2025Article
- Brain region dependent molecular signatures and myelin repair following chronic demyelination.Frontiers in cellular neuroscience · 2023Article
- Dysmyelination by Oligodendrocyte-Specific Ablation of Ninj2 Contributes to Depressive-Like Behaviors.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- Ninj2 regulates Schwann cells development by interfering laminin-integrin signaling.Theranostics · 2022Article
- As above, so below: Whole transcriptome profiling demonstrates strong molecular similarities between avian dorsal and ventral pallial subdivisions.The Journal of comparative neurology · 2021Article
- Assessment of Association between NINJ2 Polymorphisms and Suicide Attempts in an Iranian Population.Journal of molecular neuroscience : MN · 2020Article
- Application of Artificial Neural Network for Prediction of Risk of Multiple Sclerosis Based on Single Nucleotide Polymorphism Genotypes.Journal of molecular neuroscience : MN · 2020Article
- Associations Between Two Single-Nucleotide Polymorphisms in NINJ2 Gene and Risk of Psychiatric Disorders.Journal of molecular neuroscience : MN · 2020Article
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5 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Multiple sclerosis (MS) is a devastating inflammatory disease of the central nervous system (CNS) associated with loss of myelin sheaths. The role of Schwan cells in the remyelination of MS lesions has been documented. However, the detailed steps of this process are unknown. Ninjurin 2 (NINJ2) encodes an adhesion protein with high expression in Schwann cells adjoining the distal piece of injured nerve. Based on the role of this protein in neurite outgrowth, it might participate in the process of nerve regeneration after nerve damage. In the present study, we genotyped two NINJ2 single nucleotide polymorphisms (SNPs) namely rs11833579 and rs3809263 in a population of Iranian patients with MS as well as healthy individuals. The frequency of T allele of the rs3809263 was significantly higher in MS patients compared with healthy subjects (OR (95% CI) = 1.33 (1.08-1.63), adjusted P value = 0.01). TT genotype of this SNP was associated with MS risk compared with CC genotype (OR (95% CI) = 2.22 (1.37-3.57), adjusted P value = 0.009). Moreover, the rs3809263 was associated with MS risk in recessive model (OR (95% CI) = 2.09 (1.33-3.31), adjusted P value = 0.003). There were no significant difference in the alleles and genotypes frequencies of rs11833579 between cases and controls. The current research suggests contribution of NINJ2 in the pathogenesis of MS and warrants further studies for elaboration of the underlying mechanism of such contribution.
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