ArticleEuropean radiology experimental2019
Imaging features in post-mortem x-ray dark-field chest radiographs and correlation with conventional x-ray and CT.
Article in European radiology experimental, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Deformable image registration of dark-field chest radiographs for functional lung assessment.Medical physics · 2025Article
- Fourteen Deaths from Suspected Heparin Overdose in an Italian Primary-Level Hospital.Diagnostics (Basel, Switzerland) · 2023Article
- Exploration of the X-ray Dark-Field Signal in Mineral Building Materials.Journal of imaging · 2022Article
- The diagnostic value of grey-scale inversion technique in chest radiography.La Radiologia medica · 2022Article
- Dark-field chest x-ray imaging: first experience in patients with alpha1-antitrypsin deficiency.European radiology experimental · 2022Article
- X-ray dark-field chest imaging for detection and quantification of emphysema in patients with chronic obstructive pulmonary disease: a diagnostic accuracy study.The Lancet. Digital health · 2021Article
- X-ray dark field imaging: a tool for early diagnosis of emphysema in chronic obstructive pulmonary disease?The Lancet. Digital health · 2021Article
- In-vivo X-ray dark-field computed tomography for the detection of radiation-induced lung damage in mice.Physics and imaging in radiation oncology · 2021Article
- Correlation of image quality parameters with tube voltage in X-ray dark-field chest radiography: a phantom study.Scientific reports · 2021Article
- Whole-body x-ray dark-field radiography of a human cadaver.European radiology experimental · 2021Article
- A proof-of principal study using phase-contrast imaging for the detection of large airway pathologies after lung transplantation.Scientific reports · 2020Article
- X-ray Fokker-Planck equation for paraxial imaging.Scientific reports · 2019Article
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21 authors.
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Abstract
backgroundAlthough x-ray dark-field imaging has been intensively investigated for lung imaging in different animal models, there is very limited data about imaging features in the human lungs. Therefore, in this work, a reader study on nine post-mortem human chest x-ray dark-field radiographs was performed to evaluate dark-field signal strength in the lungs, intraobserver and interobserver agreement, and image quality and to correlate with findings of conventional x-ray and CT.
methodsIn this prospective work, chest x-ray dark-field radiography with a tube voltage of 70 kVp was performed post-mortem on nine humans (3 females, 6 males, age range 52-88 years). Visual quantification of dark-field and transmission signals in the lungs was performed by three radiologists. Results were compared to findings on conventional x-rays and 256-slice computed tomography. Image quality was evaluated. For ordinal data, median, range, and dot plots with medians and 95% confidence intervals are presented; intraobserver and interobserver agreement were determined using weighted Cohen κ.
resultsDark-field signal grading showed significant differences between upper and middle (p = 0.004-0.016, readers 1-3) as well as upper and lower zones (p = 0.004-0.016, readers 1-2). Median transmission grading was indifferent between all lung regions. Intraobserver and interobserver agreements were substantial to almost perfect for grading of both dark-field (κ = 0.793-0.971 and κ = 0.828-0.893) and transmission images (κ = 0.790-0.918 and κ = 0.700-0.772). Pulmonary infiltrates correlated with areas of reduced dark-field signal. Image quality was rated good for dark-field images.
conclusionsChest x-ray dark-field images provide information of the lungs complementary to conventional x-ray and allow reliable visual quantification of dark-field signal strength.
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