Evidence map›Paper›PMID 31292763›Full record

ArticleGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2019

Paraoxonase 1 (PON1) promoter (-107T/C) and coding region (192Q/R and 55L/M) genetic variations in pseudoexfoliation syndrome and pseudoexfoliative glaucoma risk.

Birsen Can Demirdöğen, Canan Koçan Akçin, Ezgi Göksoy, Gizem Yakar, Tuğçe Öztepe, Sinem Demirkaya-Budak, Sinan Oflaz

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In one paragraph

Article in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Birsen Can DemirdöğenDepartment of Biomedical Engineering, TOBB University of Economics and Technology, Söğütözü, 06531, Ankara, Turkey. bcandemirdogen@etu.edu.tr.ORCID http://orcid.org/0000-0002-1536-6123
Canan Koçan AkçinDepartment of Biomedical Engineering, TOBB University of Economics and Technology, Söğütözü, 06531, Ankara, Turkey.
Ezgi GöksoyDepartment of Biomedical Engineering, TOBB University of Economics and Technology, Söğütözü, 06531, Ankara, Turkey.
Gizem YakarDepartment of Biomedical Engineering, TOBB University of Economics and Technology, Söğütözü, 06531, Ankara, Turkey.
Tuğçe ÖztepeDepartment of Biomedical Engineering, TOBB University of Economics and Technology, Söğütözü, 06531, Ankara, Turkey.
Sinem Demirkaya-BudakDepartment of Biomedical Engineering, TOBB University of Economics and Technology, Söğütözü, 06531, Ankara, Turkey.
Sinan OflazDepartment of Biomedical Engineering, TOBB University of Economics and Technology, Söğütözü, 06531, Ankara, Turkey.
TOBB University of Economics and Technology · TR

Funding

TÜBİTAK 315S190
6 · The paper itself

Abstract

purposePseudoexfoliation syndrome (PEX) is characterized by the accumulation of microscopic extracellular material in the anterior chamber of the eye and can lead to the development of pseudoexfoliative glaucoma (PEG) in some patients. The pathogenesis of PEX is not fully understood, and there are no objective biomarkers for its early diagnosis. Recent research has indicated that oxidative stress and inflammation might play a role in the pathophysiology of the production of pseudoexfoliation material. Therefore, in the present study, we aimed to analyze the possible association between three genetic variants of paraoxonase 1 (PON1), a well-recognized antioxidant and anti-inflammatory enzyme, and PEX/PEG.

methodsThe study population consisted of patients with PEX (n = 150), patients with PEG (n = 150), and control subjects (n = 150). PON1 -107T/C, 192Q/R, and 55L/M genotypes were determined using PCR followed by restriction fragment length polymorphism analysis. The correlation between these genetic alterations and clinical visual characteristics was also investigated.

resultsThe minor allele frequencies and genotype distributions of PON1 did not differ significantly between the PEG, PEX, and control groups. Moreover, PON1 genotypes did not significantly influence visual clinical parameters in stratification analysis. On the other hand, in correlation analysis, pattern standard deviation was significantly correlated with the -107T/C genotypes in PEX group. In addition, intraocular pressure was correlated with the 55L/M genotypes and mean deviation was correlated with the -107T/C genotypes in the control group. Furthermore, intraocular pressure was significantly inversely correlated with sex (r =  - 0.116, P = 0.011) in the overall study group. Logistic regression analysis showed that having a PON1 -107TC or CC genotype is significantly associated with PEX (OR = 1.909, P = 0.020).

conclusionsThis study, for the first time, analyzed the relationship between PON1 genetic variants, clinical visual parameters, and PEX/PEG. The results indicated a possible role for the PON1 promoter variant in PEX.

Indexed as

Genetic Predisposition to DiseasePolymorphism, GeneticAgedAged, 80 and overAryldialkylphosphataseDNAExfoliation SyndromeFemaleGene FrequencyGenotypeGlaucomaHumansIntraocular PressureMaleMiddle AgedPromoter Regions, GeneticAryldialkylphosphataseDNAPON1 protein, humanIOPMean deviationPattern standard deviationPolymorphismVisual field score

Identifiers

PMID31292763
OpenAlexW2957723240

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.