Evidence map›Paper›PMID 31292752›Full record

Trial reportEuropean journal of nutrition2020

Influence of a 3-month low-calorie Mediterranean diet compared to the vegetarian diet on human gut microbiota and SCFA: the CARDIVEG Study.

Giuditta Pagliai, Edda Russo, Elena Niccolai, Monica Dinu, Vincenzo Di Pilato, Alessandro Magrini, Gianluca Bartolucci, Simone Baldi, Marta Menicatti, Betti Giusti and 5 more

Open access · greenAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in European journal of nutrition, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 98 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
98citing papers in PubMed, 9 pooled it
5.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

98 citing papers in PubMed, 9 syntheses or guidelines pooled it, 152 citations in OpenAlex.

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  10. Nutrients · 2024
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  11. Consumption of yacon flour and energy-restricted diet increased the relative abundance of intestinal bacteria in obese adults.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2023
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38 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 1 country.

Giuditta Pagliai *Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
Edda Russo *Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
Elena NiccolaiDepartment of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
Monica DinuDepartment of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
Vincenzo Di PilatoDepartment of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
Alessandro MagriniDepartment of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
Gianluca BartolucciDepartment of Neurosciences, Psychology, Drug Research and Child Health Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Viale Pieraccini 6, 50139, Florence, Italy.
Simone BaldiDepartment of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
Marta MenicattiDepartment of Neurosciences, Psychology, Drug Research and Child Health Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Viale Pieraccini 6, 50139, Florence, Italy.
Betti GiustiDepartment of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
Rossella MarcucciDepartment of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
Gian Maria RossoliniDepartment of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
Alessandro CasiniDepartment of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
Francesco Sofi *Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.ORCID http://orcid.org/0000-0001-7113-7424
Amedeo Amedei *Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy. amedeo.amedei@unifi.it.
University of Florence · ITAzienda Ospedaliero-Universitaria Careggi · IT

Funding

Regione Toscana 4042.16092014.066000029
6 · The paper itself

Abstract

purposeWe evaluated the effect of low-calorie mediterranean (MD) and vegetarian (VD) diets on gut microbiome (GM) composition and short-chain-fatty acids (SCFA) production.

methodsWe performed next generation sequencing (NGS) of 16S rRNA and SCFA analysis on fecal samples of 23 overweight omnivores (16 F; 7 M) with low-to-moderate cardiovascular risk. They were randomly assigned to a VD or MD, each lasting 3 months, with a crossover study design.

resultsDietary interventions did not produce significant diversity in the GM composition at higher ranks (family and above), neither between nor within MD and VD, but they did it at genus level. MD significantly changed the abundance of Enterorhabdus, Lachnoclostridium and Parabacteroides, while VD significantly affected the abundance of Anaerostipes, Streptococcus, Clostridium sensu stricto, and Odoribacter. Comparison of the mean variation of each SCFA between MD and VD showed an opposite and statistically significant trend for propionic acid (+ 10% vs - 28%, respectively, p = 0.034). In addition, variations of SCFA were negatively correlated with changes of some inflammatory cytokines such as VEGF, MCP-1, IL-17, IP-10 and IL-12, only after MD. Finally, correlation analyses showed a potential relationship-modulated by the two diets-between changes of genera and changes of clinical and biochemical parameters.

conclusionsA short-term dietary intervention with MD or VD does not induce major change in the GM, suggesting that a diet should last longer than 3 months for scratching the microbial resilience. Changes in SCFA production support their role in modulating the inflammatory response, thus mediating the anti-inflammatory and protective properties of MD.

Indexed as

Diet, MediterraneanGastrointestinal MicrobiomeCross-Over StudiesDiet, VegetarianHumansRNA, Ribosomal, 16SRNA, Ribosomal, 16SCardiovascular diseasesCytokinesMediterranean dietMicrobiotaSCFAVegetarian diet

Identifiers

PMID31292752
OpenAlexW2956545865

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.