ArticleKnee surgery, sports traumatology, arthroscopy : official journal of the ESSKA2020
Early knee osteoarthritis prevalence is highest among middle-aged adult females with obesity based on new set of diagnostic criteria from a large sample cohort study in the Japanese general population.
Article in Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 65 citations in OpenAlex.
- Evidence on risk factors for knee osteoarthritis in middle-older aged: a systematic review and meta analysis.Journal of orthopaedic surgery and research · 2023Pooled it
- Combined mode-kinetic chain exercise with and without core stability exercises on patients with knee osteoarthritis.BMC musculoskeletal disorders · 2026Trial
- Reduced serum levels of anti-Mullerian hormone is a putative biomarker of early knee osteoarthritis in middle-aged females at menopausal transition.Scientific reports · 2021Trial
- Biologics or surgery for moderate knee osteoarthritis? a patient-centered framework for short-term relief and long-term outcomes.Journal of orthopaedic surgery and research · 2026Review
- Association between body composition, knee synovial effusion, and serum glutamate in middle-aged women with knee osteoarthritis: a cross-sectional study.Scientific reports · 2026Article
- Steeper medial posterior tibial slope is associated with medial meniscal extrusion and early-onset knee osteoarthritis in middle-aged Japanese women: A longitudinal cohort study.Journal of experimental orthopaedics · 2026Article
- Quantitative analysis of bony and soft tissue contributions to varus deformity across knee osteoarthritis stages.Journal of experimental orthopaedics · 2026Article
- Association between knee osteoarthritis and volumetric bone mineral density.Osteoarthritis and cartilage open · 2026Article
- Sex-specific patterns and limited bilateral symmetry in coronal knee alignment: Insights from the modified coronal plane alignment of the knee classification.Osteoarthritis and cartilage open · 2026Article
- Type 2 Diabetes Mellitus Modifies the Association Between Exercise Therapy and Injury Risk and Long-Term Outcomes in Patients with Knee Osteoarthritis: A Retrospective Cohort Study.Journal of pain research · 2026Article
- Body Mass Index and Spinopelvic Alignment as Predictors of Incident Knee Osteoarthritis: An 8-Year Longitudinal Study from the TOEI Cohort of Older Japanese Women.Journal of clinical medicine · 2025Article
- Personalized Medication for Chronic Diseases Using Multimodal Data-Driven Chain-of-Decisions.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Ultrasound-based radiomics and machine learning for enhanced diagnosis of knee osteoarthritis: Evaluation of diagnostic accuracy, sensitivity, specificity, and predictive value.European journal of radiology open · 2025Article
- Normative values of radiographic parameters in coronal plane lower limb alignment in a general Japanese population: A cross-sectional study in the Iwaki cohort.Journal of experimental orthopaedics · 2025Article
- Relationship between ultrasonographic findings and subscales of the Knee Injury and Osteoarthritis Outcome Score in patients with early knee osteoarthritis: a multicenter study.Journal of medical ultrasonics (2001) · 2025Observational
- The Effect of Thigh Muscle Forces on Knee Contact Force in Female Patients with Severe Knee Osteoarthritis.Bioengineering (Basel, Switzerland) · 2024Article
- Relationship between preoperative and discharge evaluations in patients receiving around-the-knee osteotomy.Journal of physical therapy science · 2024Article
- Greater medial proximal tibial slope is associated with bone marrow lesions in middle-aged women with early knee osteoarthritis.Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology · 2023Article
- Medial Meniscal Extrusion in Patients With Medial Meniscus Root Tears: A Systematic Review and Meta-analysis.Orthopaedic journal of sports medicine · 2023Review
- Effusion detected by ultrasonography and overweight may predict the risk of knee osteoarthritis in females with early knee osteoarthritis: a retrospective analysis of Iwaki cohort data.BMC musculoskeletal disorders · 2022Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeA few new criteria for early detection and prevention of early knee osteoarthritis (EKOA) have been proposed. However, its prevalence, risk factors, relationship with function and prognosis have not been clarified. The purpose of this study was to investigate the prevalence of EKOA and its risk factors in the Japanese general population.
methodsA total of 1104 volunteers (443 males, 661 females) who participated in the Iwaki cohort study in Japan were enrolled in this cross-sectional study. Their bilateral weight-bearing anterior-posterior knee radiographs were classified by Kellgren-Lawrence (KL) grade. EKOA (KL grade 0/1) was defined according to the following criteria: knee injury and osteoarthritis outcome score < 85%, joint line tenderness, and crepitus and its prevalence among age-sex groups was calculated. Logistic regression analyses were performed to determine the risk factors for EKOA.
resultsEight hundred and twenty-two participants had KL grade 0/1, and the EKOA prevalence was 9.5% in males and 15.0% in females (p = 0.011). The prevalence of EKOA increased with age. The highest prevalence was noted in females aged 50-59 years. Logistic regression analysis showed that the risk factors for EKOA were age (p < 0.001, odds ratio (OR) 1.1), female sex (p = 0.002, OR 2.5), high body mass index (p < 0.001, OR 1.2), and history of knee injury (p < 0.001, OR 21.7).
conclusionsThe highest EKOA prevalence was observed in middle adult females (50-59 years old). The risk factors for EKOA were female sex, ageing, obesity and knee injury history, which were extremely similar to those of definitive knee osteoarthritis. LEVEL OF EVIDENCE: Level I in diagnostic studies-investigating a diagnostic test.
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