ArticlePediatric radiology2019
Low b-value (50-100) diffusion-weighted images detect significantly more hyperintense liver lesions in children than T2-weighted images.
Article in Pediatric radiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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9 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.
- Best practices for pediatric liver MRI: guidelines from members of the Society for Pediatric Radiology Magnetic Resonance and Abdominal Imaging Committees.Pediatric radiology · 2025Guideline
- Differentiation of hepatocellular carcinoma from hepatic hemangioma using diffusion-derived vessel density map-based radiomics features.Frontiers in oncology · 2026Article
- Can a low b-value diffusion-weighted imaging sequence replace the standard T2-weighted fluid-sensitive sequence in breast MRI? A single-center prospective study.European radiology · 2025Article
- Multi-band vs. conventional diffusion-weighted MRI of the abdomen in children and young adults.Abdominal radiology (New York) · 2025Article
- Detection of bone marrow metastases in children and young adults with solid cancers with diffusion-weighted MRI.Skeletal radiology · 2023Article
- Article
- One-stop local and whole-body staging of children with cancer.Pediatric radiology · 2022Review
- Liver magnetic resonance imaging: how we do it.Pediatric radiology · 2022Review
- The value of multiparametric histogram features based on intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI) for the differential diagnosis of liver lesions.Annals of translational medicine · 2020Article
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLow b-value (50-100 s/mm
objectiveThe purpose of the study was to compare the sensitivity of low b-value DWI images and T2-W images in detecting focal liver lesions in children. MATERIALS AND
methodsA retrospective review of liver magnetic resonance imaging (MRI) to assess focal liver lesions in 50 children (22 males, 28 females; age: 2 months to 17 years [mean: 10.9 years]) was performed. Two radiologists reviewed both low b-value DWI and T2-W sequences independently on different occasions to note lesions, the smallest lesion size and the location. A consensus reading of the entire MRI examination and a correlation with follow-up, other imaging modalities and pathology in available cases were used to determine the final number of lesions as a reference standard. The average number of lesions per patient detected by both readers on each sequence was compared with each other and with the reference standard using the signed-rank test. The smallest lesions detected by each sequence were compared using the paired t-test.
resultsOne hundred seventy hyperintense lesions were identified on consensus review to serve as the reference standard. The average number of lesions identified by both readers on low b-value DWI was 134 (79%) and on T2-W was 95 (56%). There was excellent interobserver agreement for detection of lesions on low b-value DWI (intraclass correlation coefficient [ICC]=0.96 [0.93-0.98]) and T2-W (ICC=0.85 [0.75-0.91]), with slightly better agreement on low b-value DWI. Both readers identified significantly more number of lesions on low b-value DWI compared to T2-W (Reader 1: P=0.0036, Reader 2: P=0.0001). Compared to the reference standard (mean number of lesions: 3.45), T2-W detected significantly fewer lesions (mean number of lesions: 1.91; P=0.0001) while there was no significant difference in lesion detection on low b-value DWI (mean number of lesions: 2.68; P=0.1527). Low b-value DWI and T2-W were not significantly different in identifying the smallest lesion size (Reader 1: P=0.19, Reader 2: P=0.47).
conclusionLow b-value DWI images are more sensitive than T2-W sequences in detecting hyperintense focal liver lesions in children.
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