Evidence map›Paper›PMID 31292655›Full record

ArticleMedical mycology2019

A clinical approach to respiratory disease in patients with hematological malignancy, with a focus on respiratory infection.

J Periselneris, J S Brown

Registry-linked trialOpen access · bronzeAbstract read
In one paragraph

Article in Medical mycology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06350526 (Radiological Characterization of Pulmonary Involvement in Patients With Hematological Diseases), which is not on this map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.3field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06350526 completednot on this mapstarted 2024, after this paper: background citation

Radiological Characterization of Pulmonary Involvement in Patients With Hematological Diseases

TypeobservationalSponsorNew Valley UniversityRan2024 to 2025Enrolled148ConditionsHematologic DiseasesArmsComplete Blood Count, C-reactive protein, O2 saturation, Serum ferritin and D-dimer, Liver and renal function tests
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Evaluation of the DynamikerInfectious diseases and therapy · 2022
    Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

J PeriselnerisRespiratory Department, King's College Hospital.
J S BrownCentre for Inflammation & Tissue Repair, University College London.
Centre for Inflammation Research · GBKing's College Hospital · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Respiratory complications, in particular infections, are common in the setting of hematological malignancy and after hematopoetic stem cell transplant. The symptoms can be nonspecific; therefore, it can be difficult to identify and treat the cause. However, an understanding of the specific immune defect, clinical parameters such as speed of onset, and radiological findings, allows the logical diagnostic and treatment plan to be made. Radiological findings can include consolidation, nodules, and diffuse changes such as ground glass and tree-in-bud changes. Common infections that induce these symptoms include bacterial pneumonia, invasive fungal disease, Pneumocystis jirovecii and respiratory viruses. These infections must be differentiated from inflammatory complications that often require immune suppressive treatment. The diagnosis can be refined with the aid of investigations such as bronchoscopy, computed tomography (CT) guided lung biopsy, culture, and serological tests. This article gives a schema to approach patients with respiratory symptoms in this patient group; however, in the common scenario of a rapidly deteriorating patient, treatment often has to begin empirically, with the aim to de-escalate treatment subsequently after targeted investigations.

Indexed as

Hematologic NeoplasmsHumansRespiratory Tract Infectionshematological malignancyinvasive mould diseaserespiratory infection

Identifiers

PMID31292655
PMCPMC7107627
OpenAlexW2962234504

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.