ArticleNature2019
Notum produced by Paneth cells attenuates regeneration of aged intestinal epithelium.
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In one paragraph
Article in Nature, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 153 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
153citing papers in PubMed, 1 pooled it
11.8field-weighted citation impact, top 1% of its field
What it found
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Who cites it
153 citing papers in PubMed, 1 synthesis or guideline pooled it, 270 citations in OpenAlex.
- Paneth Cells: Recent Updates on Elucidating Therapeutic Implications in Gastroenterological Disease Management.Current medicinal chemistry · 2025Pooled it
- Tissue and cellular spatiotemporal dynamics in colon aging.Nature biotechnology · 2026Article
- TNFR1 signaling connects inflammation to impaired fatty acid oxidation to drive intestinal stem cell aging.Nature aging · 2026Article
- Golgi organization regulates stem cell function in the small intestine.Nature communications · 2026Article
- Interplay of the ENS and Microbiota With Murine Gut Epithelium-Derived Organoids in Aging.Aging cell · 2026Article
- Single-nucleus interrogation of primate small intestinal aging reveals NCoR1 decline as a conserved feature that is reversed by metformin.Nature aging · 2026Article
- Cannabidiol triggers fatty acids β-oxidation mediated by Stat2 to facilitate intestinal stem cells regeneration post radiation.Experimental & molecular medicine · 2026Article
- Maladaptive Inflammatory Signaling in Old Mice Impairs Colonic Regeneration by Promoting a Sustained Fetal-Like Epithelial State.Aging cell · 2026Article
- Translational Geroscience Strategies for Delaying Multimorbidity.ACS pharmacology & translational science · 2026Review
- Attenuation of the CpG island methylator phenotype and lack of WNT signalling activation restrains Kras mutant intestinal neoplasia.British journal of cancer · 2026Article
- Paneth cell SIRT1 deficiency increases intestinal stress resistance by modulating the gut microbiota.EMBO reports · 2026Article
- Paneth cells as orchestrators of epithelial barrier defense and emerging therapeutic targets in inflammatory bowel disease.Seminars in immunopathology · 2026Review
- In vitro modelling of extracellular matrix changes during skin aging: from static 2D to 3D dynamic microphysiological systems.Microsystems & nanoengineering · 2026Review
- Histone 3 lysine 36 trimethylation by SETD2 shapes an epigenetic landscape in intestinal stem cells to orchestrate lipid metabolism and attenuate cell senescence.Cell death & disease · 2026Article
- Single-nucleus multi-omics analysis of mouse small-intestinal Lgr5+ cell populations reveals Foxa3-induced Paneth cell-lineage differentiation.Communications biology · 2026Article
- Microbiota from young mice restore the function of aged ISCs.Stem cell reports · 2026Article
- Liver X receptor: A potential target for inflammatory bowel disease and colorectal cancer (Review).Molecular medicine reports · 2026Review
- Intestinal aging-related immune dysfunction: mechanisms and interventions.Acta biochimica et biophysica Sinica · 2026Review
- Anti-uPAR CAR T cells reverse and prevent aging-associated defects in intestinal regeneration and fitness.Nature aging · 2026Article
- Intestinal epithelial cells in health and disease.Tissue barriers · 2026Review
93 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
24 authors at 9 institutions in 2 countries.
Nalle PentinmikkoInstitute of Biotechnology, HiLIFE, University of Helsinki, Helsinki, Finland.
Sharif Iqbal *Institute of Biotechnology, HiLIFE, University of Helsinki, Helsinki, Finland.
Miyeko Mana *The David H. Koch Institute for Integrative Cancer Research at MIT, Department of Biology, MIT, Cambridge, MA, USA.
Simon AnderssonInstitute of Biotechnology, HiLIFE, University of Helsinki, Helsinki, Finland.
Armand B CognettaThe Skaggs Institute for Chemical Biology, Department of Chemical Physiology, The Scripps Research Institute, La Jolla, CA, USA.
Radu M SuciuThe Skaggs Institute for Chemical Biology, Department of Chemical Physiology, The Scripps Research Institute, La Jolla, CA, USA.
Jatin RoperDepartment of Medicine, Division of Gastroenterology, Duke University, Durham, NC, USA.
Kalle LuopajärviInstitute of Biotechnology, HiLIFE, University of Helsinki, Helsinki, Finland.
Eino MarkelinInstitute of Biotechnology, HiLIFE, University of Helsinki, Helsinki, Finland.
Swetha GopalakrishnanInstitute of Biotechnology, HiLIFE, University of Helsinki, Helsinki, Finland.
Olli-Pekka SmolanderInstitute of Biotechnology, HiLIFE, University of Helsinki, Helsinki, Finland.
Santiago NaranjoThe David H. Koch Institute for Integrative Cancer Research at MIT, Department of Biology, MIT, Cambridge, MA, USA.
Tuure SaarinenObesity Research Unit, Research Programs Unit, Diabetes and Obesity, University of Helsinki, Helsinki, Finland.
Anne JuutiAbdominal Center, Department of Gastrointestinal Surgery, Helsinki University Hospital, Helsinki, Finland.
Kirsi PietiläinenObesity Research Unit, Research Programs Unit, Diabetes and Obesity, University of Helsinki, Helsinki, Finland.
Petri AuvinenInstitute of Biotechnology, HiLIFE, University of Helsinki, Helsinki, Finland.
Ari RistimäkiDepartment of Pathology, Research Programs Unit and HUSLAB, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Nitin GuptaAtlanta Gastroenterology Associates, Atlanta, GA, USA.
Tuomas TammelaCancer Biology and Genetics, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Tyler JacksThe David H. Koch Institute for Integrative Cancer Research at MIT, Department of Biology, MIT, Cambridge, MA, USA.
David M SabatiniThe David H. Koch Institute for Integrative Cancer Research at MIT, Department of Biology, MIT, Cambridge, MA, USA.
Benjamin F CravattThe Skaggs Institute for Chemical Biology, Department of Chemical Physiology, The Scripps Research Institute, La Jolla, CA, USA.
Ömer H YilmazThe David H. Koch Institute for Integrative Cancer Research at MIT, Department of Biology, MIT, Cambridge, MA, USA.
Pekka KatajistoInstitute of Biotechnology, HiLIFE, University of Helsinki, Helsinki, Finland. pekka.katajisto@helsinki.fi.
University of Helsinki · FIHelsinki University Hospital · FIScripps Research Institute · USAllen Institute · USKoch Institute for Integrative Cancer Research At MITAtlanta Gastroenterology Associates · USDuke University · USHoward Hughes Medical Institute · USMemorial Sloan Kettering Cancer Center · US
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Elisa de Stanchina · 1985 to 2026
$347.4MVIRUS PRODUCTION COREP30CA014051 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI Michael Birnbaum · 1985 to 2026
$93.9MPRE-DOCTORAL TRAINING IN THE BIOLOGICAL SCIENCEST32GM007287 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI BELL, STEPHEN P., KEATING, AMY E · 1985 to 2019
$40.8MUnderstanding and Improving Platinum Anticancer DrugsR01CA034992 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI YILMAZ, OMER · 1985 to 2018
$6.8MRegulation of the Intestinal Stem Cell Niche in AgingR00AG045144 · NIA · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI YILMAZ, OMER · 2014 to 2016
$740kNCI NIH HHS P30 CA008748NCI NIH HHS P30 CA014051NCI NIH HHS R01 CA034992NIA NIH HHS R00 AG045144NIGMS NIH HHS T32 GM007287
Abstract
A decline in stem cell function impairs tissue regeneration during ageing, but the role of the stem-cell-supporting niche in ageing is not well understood. The small intestine is maintained by actively cycling intestinal stem cells that are regulated by the Paneth cell niche
Indexed as
AgingCellular SenescenceRegenerationAnimalsEsterasesFemaleHumansIntestinal MucosaMaleMechanistic Target of Rapamycin Complex 1MicePaneth CellsPPAR alphaReceptors, G-Protein-CoupledStem Cell NicheStem CellsEsterasesLgr5 protein, mouseMechanistic Target of Rapamycin Complex 1Notum protein, humanNotum protein, mousePPAR alphaReceptors, G-Protein-CoupledWnt Proteins
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.