ArticleEye (London, England)2020
Clinical features and serial changes of Acanthamoeba keratitis: an in vivo confocal microscopy study.
Article in Eye (London, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 37 citations in OpenAlex.
- In vivo confocal microscopy findings from full corneal epithelial debridement and local corticosteroid for recurrent corneal erosion.Eye (London, England) · 2026Article
- Article
- Enhanced Imaging of Ocular Surface Lesions.Journal of clinical medicine · 2025Review
- Successful Treatment of Acanthamoeba Keratitis According to New Protocol with Polihexanide 0.08% Therapy: Case Report.Reports (MDPI) · 2025Article
- Diagnostic features of Acanthamoeba keratitis via in vivo confocal microscopy.Scientific reports · 2025Observational
- Targets for the diagnosis ofmSphere · 2025Article
- The pathogenesis, risk factors, diagnosis and treatment of Acanthamoeba keratitis.Frontiers in medicine · 2025Review
- Acanthamoeba keratitis: from pathophysiology to prevention, a contemporary clinical perspective.Medical hypothesis, discovery & innovation ophthalmology journal · 2025Review
- Use of in vivo confocal microscopy in suspected Acanthamoeba keratitis: a 12-year real-world data study at a Swedish regional referral center.Journal of ophthalmic inflammation and infection · 2024Article
- Artificial-Intelligence-Enhanced Analysis of In Vivo Confocal Microscopy in Corneal Diseases: A Review.Diagnostics (Basel, Switzerland) · 2024Review
- Epidemiology of and Genetic Factors Associated withPathogens (Basel, Switzerland) · 2024Review
- Infectious Keratitis in Patients Over 65: A Review on Treatment and Preserving Eyesight.Clinical interventions in aging · 2024Review
- Differentiation of acanthamoeba keratitis from other non-acanthamoeba keratitis: Risk factors and clinical features.PloS one · 2024Article
- New Frontiers inBiology · 2023Review
- AI-Based Decision-Support System for Diagnosing Acanthamoeba Keratitis Using In Vivo Confocal Microscopy Images.Translational vision science & technology · 2023Article
- Complete Recovery ofMicroorganisms · 2023Article
- Update on Corneal Confocal Microscopy Imaging.Diagnostics (Basel, Switzerland) · 2022Review
- Application Progress of High-Throughput Sequencing in Ocular Diseases.Journal of clinical medicine · 2022Review
- Article
- Corneal Changes in Acanthamoeba Keratitis at Various Levels of Severity: An In Vivo Confocal Microscopic Study.Translational vision science & technology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
purposeTo observe the clinical features and serial changes of Acanthamoeba keratitis (AK) during medical treatment by using confocal microscopy.
methodsThirty-seven patients (37 eyes) diagnosed with AK were included in this study. Confocal microscopy was used to observe the morphology, distribution, and density of Acanthamoeba cysts before and after medication. The differences between cysts and inflammatory cells were identified.
resultsAcanthamoeba cysts were detected at a rate of 94.6% (35/37) by repeated confocal microscopic examinations. The cysts consisting of a lowly light-reflective wall and a high-refractive nucleus, showed cluster or chain distribution in the corneal stroma, which was different from inflammatory cells. After medical therapy, the nucleus of cysts or peripheral corneal tissue gradually dissolved to a hollow configuration. Some of the hollow cysts existed for up to 6 months. The quantity of cysts increased after 1-2 weeks of medication in 23 patients (62.1%), and then began to decrease in 13 patients (35.1 %) who were responsive to anti-amoebic treatment.
conclusionAcanthamoeba cysts have many typical clinical features that can be identified by confocal microscopy, which may serve as a valuable tool to guide clinical evaluation and treatment of AK.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.