ArticleEye (London, England)2020
Ocular surface squamous neoplasia with intraocular tumour extension: a study of 23 patients.
Article in Eye (London, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 32 citations in OpenAlex.
- Conjunctival Squamous Cell Carcinoma Following Intravitreal Injection Through an Unrecognized CIN: A Case Report.Klinische Monatsblatter fur Augenheilkunde · 2026Article
- Enhanced Imaging of Ocular Surface Lesions.Journal of clinical medicine · 2025Review
- Spontaneously resolved invasive conjunctival squamous cell carcinoma with anterior chamber invasion in low-grade lymphoma patient.American journal of ophthalmology case reports · 2025Article
- Clinico-tomographic-pathological correlation in nodulo-ulcerative ocular surface squamous neoplasia: a study of 16 cases.International ophthalmology · 2025Article
- Establishment of a nomogram model to predict malignant risk in patients with ocular surface squamous neoplasia and ocular surface squamous epithelial tumors.Frontiers in oncology · 2025Article
- Metastatic conjunctival squamous cell carcinoma presenting as infectious sclerokeratouveitis.American journal of ophthalmology case reports · 2024Article
- Intraocular Invasion by Conjunctival Squamous Cell Carcinoma: Clinical Presentation, Histopathological Findings, and Outcome.Ocular oncology and pathology · 2024Article
- Asymptomatic chronic red eye: A surgical technique case report.International journal of surgery case reports · 2023Article
- Ocular surface squamous neoplasia in India: a study of 438 patients.International ophthalmology · 2022Article
- The role of imaging technologies for ocular surface tumors.Current opinion in ophthalmology · 2021Review
- Ocular surface squamous neoplasia: management and outcomes.Eye (London, England) · 2021Review
- Update on the Management of Ocular Surface Squamous Neoplasia.Current ophthalmology reports · 2021Article
- Intraocular Invasion of Ocular Surface Squamous Neoplasia Through a Corneal Wound.Ophthalmology and therapy · 2020Article
- Intraocular Spread of Ocular Surface Squamous Neoplasia Presenting as a Postoperative Anterior Chamber Opacity after Excisional Biopsy.Case reports in ophthalmologyArticle
- Recurrent Conjunctival Squamous Cell Carcinoma and Intraocular Tumor Extension after Topical Erythropoietin: A Case Report.Case reports in ophthalmologyArticle
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo describe the clinical features, histopathology and treatment of ocular surface squamous neoplasia (OSSN) with intraocular tumour extension.
methodsRetrospective study of 23 patients.
resultsThe mean age at presentation of OSSN with intraocular tumour extension was 48 years. Mass (52%) and pain with redness (30%) were the most common presenting complaints. The mean duration of symptoms was 9 months. History of human immunodeficiency virus (HIV) infection was present in eight (35%) patients and one (4%) had xeroderma pigmentosum. History of prior tumour excision was noted in 16 (70%) patients. The mean basal diameter was 17 mm and the mean tumour thickness was 4 mm. Fifteen (65%) tumours had a nodulo-ulcerative tumour pattern at the time of detection of intraocular extension of OSSN. Anterior chamber cells and flare was noted in five (24%) cases and two (9%) patients had secondary glaucoma. Ultrasound biomicroscopy (UBM) (n = 11) revealed blunting of anterior chamber in three (27%) cases and uveal thickening in seven (67%) cases. Over the course of follow-up, extended enucleation (n = 6; 26%) or orbital exenteration (n = 17; 74%) was required for tumour control. At a mean follow-up period of 18 months, locoregional lymph node metastasis was seen in two (9%) patients, and one patient died with systemic metastasis. On histopathology, ciliary body was involved in all (100%) cases.
conclusionMultiple tumour recurrences with history of prior tumour excision and nodulo-ulcerative tumour pattern are commonly associated with intraocular tumour extension of OSSN. UBM is a useful tool to detect intraocular extension of OSSN.
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