ArticleScientific reports2019
Serum biomarkers in people with chronic low back pain and Modic 1 changes: a case-control study.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Cytokine Patterns as Predictors of Antibiotic Treatment Effect in Chronic Low Back Pain with Modic Changes: Subgroup Analyses of a Randomized Trial (AIM Study).Journal of pain research · 2023Trial
- Proteomic analysis of serum in a population-based cohort did not reveal a biomarker for Modic changes.JOR spine · 2024Article
- No evidence of association between either Modic change or disc degeneration and five circulating inflammatory proteins.JOR spine · 2024Article
- Biomarkers for intervertebral disc and associated back pain: From diagnosis to disease prognosis and personalized treatment.JOR spine · 2023Review
- Role of C-reactive protein in the bone marrow of Modic type 1 changes.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2023Article
- Macrophage migration inhibitory factor: a potential biomarker for chronic low back pain in patients with Modic changes.RMD open · 2021Article
- Low Back Pain Exacerbation Is Predictable Through Motif Identification in Center of Pressure Time Series Recorded During Dynamic Sitting.Frontiers in physiology · 2021Article
- Functional Disruptions of the Brain in Low Back Pain: A Potential Imaging Biomarker of Functional Disability.Frontiers in neurology · 2021Article
- Serum Biomarkers for Connective Tissue and Basement Membrane Remodeling are Associated with Vertebral Endplate Bone Marrow Lesions as Seen on MRI (Modic Changes).International journal of molecular sciences · 2020Article
- Therapeutic Potential of Extracellular Vesicles in Degenerative Diseases of the Intervertebral Disc.Frontiers in bioengineering and biotechnology · 2020Review
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We aimed to compare serum biomarkers of inflammation, redox status and cartilage degradation between chronic low back pain (cLBP) patients with and without Modic 1 changes. We used a convenience sample of patients recruited from a single center, case-control study, conducted in a tertiary care center. From December, 2014 to May, 2016, 2,292 patients were consecutively screened, 34 met inclusion criteria and were prospectively enrolled in the present study. Cases (n = 13) were defined as patients with Modic 1 changes detected on MRI and controls (n = 21) as cLBP patients without (Modic 0). To assess serum biomarkers of inflammation, redox status and cartilage degradation, fasting serum samples were collected in a standardized manner and analyzed by immunoassays and spectrophotometry. Mean (95% CI) age was 44.1 (40.0-48.1) years and mean LBP duration was 72.5 (53.0-91.9) months. Serum biomarkers of inflammation (IL-1β, IL-6, IL-8 and TNF-α), redox status (total thiols, advanced oxidation protein products and carbonyl groups) and cartilage degradation (Coll2-1 and Coll2-1NO
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