Evidence map›Paper›PMID 31292501›Full record

ArticleScientific reports2019

Outbreak strain characterisation and pharyngeal carriage detection following a protracted group B meningococcal outbreak in adolescents in South-West England.

Stephen A Clark, Jay Lucidarme, Georgina Angel, Aiswarya Lekshmi, Begonia Morales-Aza, Laura Willerton, Helen Campbell, Steve J Gray, Shamez N Ladhani, Mike Wade and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Meningococcal Carriage in 'Men Having Sex With Men' With Pharyngeal Gonorrhoea.Frontiers in cellular and infection microbiology · 2021
    Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Stephen A ClarkMeningococcal Reference Unit, Public Health England, Manchester, UK. stephen.clark@phe.gov.uk.
Jay LucidarmeMeningococcal Reference Unit, Public Health England, Manchester, UK.
Georgina AngelPublic Health England South West, Bristol, UK.
Aiswarya LekshmiMeningococcal Reference Unit, Public Health England, Manchester, UK.
Begonia Morales-AzaSchool of Cellular and Molecular Medicine, University of Bristol, Bristol, UK.
Laura WillertonMeningococcal Reference Unit, Public Health England, Manchester, UK.
Helen CampbellImmunisation and Countermeasures Division, Public Health England, London, UK.
Steve J GrayMeningococcal Reference Unit, Public Health England, Manchester, UK.
Shamez N LadhaniImmunisation and Countermeasures Division, Public Health England, London, UK.
Mike WadePublic Health England South West, Bristol, UK.
Mary RamsayImmunisation and Countermeasures Division, Public Health England, London, UK.
Julie YatesPublic Health England South West, Bristol, UK.
Adam FinnSchool of Cellular and Molecular Medicine, University of Bristol, Bristol, UK.
Ray BorrowMeningococcal Reference Unit, Public Health England, Manchester, UK.
Public Health England · GBUniversity of Bristol · GB

Funding

Wellcome Trust
6 · The paper itself

Abstract

Between April 2016 and September 2017, four cases of group B meningococcal disease were reported among sixth-form college students in Bristol, UK. Culture and non-culture whole genome sequencing was utilised and demonstrated that the four genomes of the responsible ST-41 strains clustered closely on a sub-lineage of ST-41/44 clonal complex. The outbreak resulted in two fatalities. A distinct social group associated with one of the cases was selected for vaccination with 4CMenB and pharyngeal swabbing. In vitro culturing, multiple real-time PCR assays (sodC, ctrA and siaD

Indexed as

AdolescentAntigens, BacterialBacterial ProteinsBacteriological TechniquesCarrier StateDisease OutbreaksEnglandHumansMeningococcal InfectionsMeningococcal VaccinesNeisseria meningitidis, Serogroup BPharynxPhylogenyPorinsWhole Genome Sequencing4CMenB vaccineAntigens, BacterialBacterial Proteinsfactor H-binding protein, Neisseria meningitidisMeningococcal Vaccinesporin protein, NeisseriaPorins

Identifiers

PMID31292501
PMCPMC6620271
OpenAlexW2956467145

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.