Evidence map›Paper›PMID 31292483›Full record

ArticleScientific reports2019

Human menstrual blood-derived stromal/stem cells modulate functional features of natural killer cells.

Mohammad-Reza Shokri, Mahmood Bozorgmehr, Alireza Ghanavatinejad, Reza Falak, Mehdi Aleahmad, Somaieh Kazemnejad, Fazel Shokri, Amir-Hassan Zarnani

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 2 pooled it
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 2 syntheses or guidelines pooled it, 58 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Review
  6. Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Review
  12. Review
  13. Review
  14. Review
  15. Frontiers in immunology · 2024
    Article
  16. Placenta: an old organ with new functions.Frontiers in immunology · 2024
    Review
  17. Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Mohammad-Reza ShokriDepartment of Immunology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Mahmood BozorgmehrOncopathology Research Center, Iran University of Medical Sciences, Tehran, Iran.
Alireza GhanavatinejadDepartment of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Reza FalakDepartment of Immunology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran. falak.r@iums.ac.ir.
Mehdi AleahmadDepartment of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Somaieh KazemnejadReproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran.
Fazel ShokriDepartment of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Amir-Hassan ZarnaniDepartment of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. zarnania@tums.ac.ir.
Tehran University of Medical Sciences · IRAcademic Center for Education, Culture and Research · IRIran University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although natural killer (NK) cells play a crucial role in the maintenance of a successful pregnancy, their cytotoxic activity should be tightly controlled. We hypothesized that endometrial mesenchymal stromal/stem cells (eMSCs) could potentially attenuate the functional features of NK cells. Herein, we assessed immunomodulatory effects of menstrual blood-derived stromal/stem cells (MenSCs), as a surrogate for eMSCs, on NK cells function. Our results showed that MenSCs induced proliferation of NK cells. However, IFN-γ/IL-1β pretreated MenSCs significantly inhibited NK cell proliferation. Of 41 growth factors tested, MenSCs produced lower levels of insulin-like growth factor binding proteins (IGFBPs) 1-4, VEGF-A, β-NGF, and M-CSF compared to bone marrow-derived mesenchymal stem cells (BMSCs). MenSCs displayed high activity of IDO upon IFN-γ treatment. The antiproliferative potential of IFN-γ/IL-1β-pretreated MenSCs was mediated through IL-6 and TGF-β. MenSCs impaired the cytotoxic activity of NK cells on K562 cells, consistent with the lower expression of perforin, granzymes A, and B. We also observed that in vitro decidualization of MenSCs in the presence of IFN-γ reduced the inhibitory effect of MenSCs on NK cell cytotoxicity against K562 target cells. Additionally, MenSCs were found to be prone to NK cell-mediated lysis in an MHC-independent manner. Our findings imply that dysregulation of NK cells in such pregnancy-related disorders as miscarriage may stem from dysfunctioning of eMSCs.

Indexed as

AdultCell DifferentiationCell ProliferationCells, CulturedCoculture TechniquesFemaleHumansInterferon-gammaInterleukin-1betaInterleukin-6K562 CellsKiller Cells, NaturalMenstruationStromal CellsTransforming Growth Factor betaIL6 protein, humanInterferon-gammaInterleukin-1betaInterleukin-6Transforming Growth Factor beta

Identifiers

PMID31292483
PMCPMC6620360
OpenAlexW2962170140

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.