Evidence map›Paper›PMID 31292464›Full record

ArticleScientific reports2019

Statistical model choice including variable selection based on variable importance: A relevant way for biomarkers selection to predict meat tenderness.

M P Ellies-Oury, M Chavent, A Conanec, M Bonnet, B Picard, J Saracco

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.0field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 21 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 1 country.

M P Ellies-OuryUniversité Clermont Auvergne, INRA, VetAgro Sup, UMR Herbivores, F-63122, Saint-Genès-Champanelle, France. marie-pierre.ellies@inra.fr.
M ChaventINRIA Bordeaux Sud-Ouest, CQFD Team, F-33400, Talence, France.
A ConanecUniversité Clermont Auvergne, INRA, VetAgro Sup, UMR Herbivores, F-63122, Saint-Genès-Champanelle, France.
M BonnetUniversité Clermont Auvergne, INRA, VetAgro Sup, UMR Herbivores, F-63122, Saint-Genès-Champanelle, France.
B PicardUniversité Clermont Auvergne, INRA, VetAgro Sup, UMR Herbivores, F-63122, Saint-Genès-Champanelle, France.
J SaraccoINRIA Bordeaux Sud-Ouest, CQFD Team, F-33400, Talence, France.
Université Clermont Auvergne · FRCentre Inria de l'université de Bordeaux · FRInstitut de Mathématiques de Bordeaux · FRUnité Mixte de Recherche sur les Herbivores · FRVetAgro Sup · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this paper, we describe a new computational methodology to select the best regression model to predict a numerical variable of interest Y and to select simultaneously the most interesting numerical explanatory variables strongly linked to Y. Three regression models (parametric, semi-parametric and non-parametric) are considered and estimated by multiple linear regression, sliced inverse regression and random forests. Both the variables selection and the model choice are computational. A measure of importance based on random perturbations is calculated for each covariate. The variables above a threshold are selected. Then a learning/test samples approach is used to estimate the Mean Square Error and to determine which model (including variable selection) is the most accurate. The R package modvarsel (MODel and VARiable SELection) implements this computational approach and applies to any regression datasets. After checking the good behavior of the methodology on simulated data, the R package is used to select the proteins predictive of meat tenderness among a pool of 21 candidate proteins assayed in semitendinosus muscle from 71 young bulls. The biomarkers were selected by linear regression (the best regression model) to predict meat tenderness. These biomarkers, we confirm the predominant role of heat shock proteins and metabolic ones.

Indexed as

AnimalsBiomarkersCattleComputational BiologyFood QualityHeat-Shock ProteinsMeatMetabolic Networks and PathwaysModels, StatisticalRegression AnalysisBiomarkersHeat-Shock Proteins

Identifiers

PMID31292464
PMCPMC6620333
OpenAlexW2960450623

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.