Evidence map›Paper›PMID 31292387›Full record

ArticleInternal medicine (Tokyo, Japan)2019

Extreme Elevation of the Prothrombin Time-International Normalized Ratio due to a Probable Interaction between Warfarin and Flutamide.

Yasunobu Konishi, Takafumi Terada, Yoshimori Araki, Osamu Kawaguchi

Open access · diamondAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Yasunobu KonishiDepartment of Cardiac Surgery, Toyota Kosei Hospital, Japan.
Takafumi TeradaDepartment of Cardiac Surgery, Toyota Kosei Hospital, Japan.
Yoshimori ArakiDepartment of Cardiac Surgery, Toyota Kosei Hospital, Japan.
Osamu KawaguchiDepartment of Cardiac Surgery, Toyota Kosei Hospital, Japan.
Toyota Kosei Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Flutamide, a chemotherapeutic agent for prostate cancer, is known to enhance warfarin anticoagulation. However, not much is known about its pharmaceutical interaction. We herein report the case of a patient with an implanted pacemaker for atrial fibrillation with bradycardia who was on warfarin. This patient presented with deterioration of hematuria, gingival, ear, and subcutaneous bleeding. The prothrombin time-international normalized ratio was extremely elevated after starting flutamide to treat progression of prostate cancer. Fatal bleeding complications were able to be prevented by the immediate administration of prothrombin complex concentrate, but the effect of flutamide on warfarin was prolonged for about two more weeks after the withdrawal of flutamide.

Indexed as

International Normalized RatioProthrombin TimeAged, 80 and overAnticoagulantsAtrial FibrillationBlood CoagulationBlood Coagulation FactorsDrug SynergismFlutamideHemorrhageHumansMalePacemaker, ArtificialProstatic NeoplasmsWarfarinAnticoagulantsBlood Coagulation FactorsFlutamideprothrombin complex concentratesWarfarinflutamideprothrombin complex concentratewarfarin

Identifiers

PMID31292387
PMCPMC6911757
OpenAlexW2961700670

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.