ArticleThe Journal of veterinary medical science2019
Experimental infection of pigs with a classical swine fever virus isolated in Japan for the first time in 26 years.
Article in The Journal of veterinary medical science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 46 citations in OpenAlex.
- The narrow window of protection: protective efficacy of maternally derived antibodies against virulent classical swine fever virus in Japan.Veterinary research · 2025Article
- Oral infectivity and 50% porcine infectious dose of classical swine fever virus JPN/1/2018 strain isolated from the first case in Japan.The Journal of veterinary medical science · 2025Article
- Classical swine fever: Unveiling the complexity through a multifaceted approach.Open veterinary journal · 2024Review
- Pathological Characteristics of Domestic Pigs Orally Infected with the Virus Strain Causing the First Reported African Swine Fever Outbreaks in Vietnam.Pathogens (Basel, Switzerland) · 2023Article
- Development of an Effective Oral Vaccine Dissemination Strategy against Classical Swine Fever for Wild Boar in Gifu Prefecture, Japan.Transboundary and emerging diseases · 2023Article
- Haplotype of Wild Korean Boars Infected by Classical Swine Fever Virus Subgenotype 2.1d.Animals : an open access journal from MDPI · 2022Article
- Measuring impact of vaccination among wildlife: The case of bait vaccine campaigns for classical swine fever epidemic among wild boar in Japan.PLoS computational biology · 2022Article
- Article
- Immunohistochemical analysis of the distribution of classical swine fever (CSF) viral antigen in boar-pig hybrids and pigs four weeks after infection.The Journal of veterinary medical science · 2022Article
- Characteristics of Classical Swine Fever Virus Variants Derived from Live Attenuated GPEViruses · 2021Article
- The formation process of button ulcers in pigs experimentally infected with a subgenotype 2.1 isolate of classical swine fever virus.The Journal of veterinary medical science · 2021Article
- Transboundary Animal Diseases, an Overview of 17 Diseases with Potential for Global Spread and Serious Consequences.Animals : an open access journal from MDPI · 2021Review
- Epidemiological analysis of classical swine fever in wild boars in Japan.BMC veterinary research · 2021Article
- Anti-Classical Swine Fever Virus Strategies.Microorganisms · 2021Review
- Article
- Self-Assembling Nanovaccine Enhances Protective Efficacy Against CSFV in Pigs.Frontiers in immunology · 2021Article
- Estimation of the Lethality Rate, Recovery Rate, and Case Fatality Ratio of Classical Swine Fever in Japanese Wild Boar: An Analysis of the Epidemics From September 2018 to March 2019.Frontiers in veterinary science · 2021Article
- Toward better control of classical swine fever in wild boars: susceptibility of boar-pig hybrids to a recent Japanese isolate and effectiveness of a bait vaccine.Veterinary research · 2020Article
- Monitoring relative abundance index and age ratios of wild boar (Sus scrofa) in small scale population in Gifu prefecture, Japan during classical swine fever outbreak.The Journal of veterinary medical science · 2020Article
- Risk Assessment of African Swine Fever Virus Exposure toPathogens (Basel, Switzerland) · 2020Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Following an outbreak of classical swine fever (CSF) in Japan, 2018, CSFV JPN/1/2018 was isolated from an infected pig sample. In this study, we carried out a comparative experimental infection in pigs using this strain and the highly virulent ALD strain and compared outcomes, including clinical manifestation, virus shedding patterns and antibody responses. Although pigs inoculated orally or intramuscularly with JPN/1/2018 developed hyperthermia and had decreased leucocyte numbers, they survived for the whole experimental period and showed less severe clinical signs than those infected with the ALD strain. We confirmed the presence of characteristic multifocal infarction of the margin of the spleen that arises following infection with JPN/1/2018, albeit that this finding was not observed in all infected pigs. Both viruses efficiently spread to contact pigs in a similar manner, suggesting in transmissibility between the two strains. Viral RNAs were detected in all clinical samples, especially whole blood samples, before the pigs developed hyperthermia until at least approximately 2 weeks after inoculation. Our findings will be valuable for the investigations into epidemic events occurring in Japan and for establishing diagnostic strategies and control measures against CSF.
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