Evidence map›Paper›PMID 31292246›Full record

ArticleJournal of virology2019

Replicons of a Rodent Hepatitis C Model Virus Permit Selection of Highly Permissive Cells.

Raphael Wolfisberg, Kenn Holmbeck, Louise Nielsen, Amit Kapoor, Charles M Rice, Jens Bukh, Troels K H Scheel

Open access · bronzeAbstract read
In one paragraph

Article in Journal of virology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Identification of claudin-3 as an entry factor for rat hepacivirus.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. The Bank Vole (Viruses · 2021
    Article
  16. Review
  17. Article
  18. Animal Models Used in Hepatitis C Virus Research.International journal of molecular sciences · 2020
    Review
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Raphael WolfisbergCopenhagen Hepatitis C Program (CO-HEP), Department of Infectious Diseases, Hvidovre Hospital, and Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0002-6191-2084
Kenn HolmbeckCopenhagen Hepatitis C Program (CO-HEP), Department of Infectious Diseases, Hvidovre Hospital, and Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Louise NielsenCopenhagen Hepatitis C Program (CO-HEP), Department of Infectious Diseases, Hvidovre Hospital, and Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Amit KapoorCenter for Vaccines and Immunity, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio, USA.
Charles M RiceLaboratory of Virology and Infectious Disease, The Rockefeller University, New York, New York, USA.
Jens BukhCopenhagen Hepatitis C Program (CO-HEP), Department of Infectious Diseases, Hvidovre Hospital, and Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Troels K H ScheelCopenhagen Hepatitis C Program (CO-HEP), Department of Infectious Diseases, Hvidovre Hospital, and Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark tscheel@sund.ku.dk.ORCID 0000-0003-1545-4067
University of Copenhagen · DKNationwide Children's Hospital · USRockefeller University · US

Funding

Analysis of immunity, viral adaptation and pathogenesis in a new mouse model of HCV-related rodent hepacivirus infectionR01AI131688 · NIAID · ROCKEFELLER UNIVERSITY · PI RICE, CHARLES M · 2017 to 2021
$3.2M
A systematic analysis of small RNA interactions during RNA virus infectionsR01AI116943 · NIAID · ROCKEFELLER UNIVERSITY · PI RICE, CHARLES M · 2016 to 2020
$3.0M
Host response and liver disease in a hepatitis C-like virus rat modelR01AI137567 · NIAID · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI KAPOOR, AMIT · 2018 to 2022
$2.5M
NIAID NIH HHS R01 AI116943NIAID NIH HHS R01 AI131688NIAID NIH HHS R01 AI137567
6 · The paper itself

Abstract

Animal hepaciviruses represent promising surrogate models for hepatitis C virus (HCV), for which there are no efficient immunocompetent animal models. Experimental infection of laboratory rats with rodent hepacivirus isolated from feral

Indexed as

Models, BiologicalVirus ReplicationAnimalsAntiviral AgentsHepacivirusHepatitis C, ChronicHepatocytesMiceMutant ProteinsMutationRatsSofosbuvirViral Nonstructural ProteinsAntiviral AgentsMutant ProteinsSofosbuvirViral Nonstructural Proteinsanimal modelsantiviral agentshepacivirushepatitis C virusmicro-RNAreplicationreplicon

Identifiers

PMID31292246
PMCPMC6744251
OpenAlexW2961213475

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.