Evidence map›Paper›PMID 31292168›Full record

ArticleBioscience reports2019

Long non-coding RNA SNHG5 promotes glioma progression via miR-205/E2F3 axis.

Xiaojian Li, Liang Liu, Yidan Luo, Sitong Cui, Wei Chen, Ailiang Zeng, Yan Shi, Liangsheng Luo

Open access · goldAbstract read
In one paragraph

Article in Bioscience reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.1field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
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  5. Transcription Factors with Targeting Potential in Gliomas.International journal of molecular sciences · 2022
    Review
  6. Review
  7. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Xiaojian LiDepartment of Neurosurgery, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China.
Liang LiuDepartment of Neurosurgery, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China.
Yidan LuoSchool of Pharmacy, Nanjing Medical University, Nanjing 211166, China.
Sitong CuiDepartment of Neurosurgery, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China.
Wei ChenDepartment of Neurosurgery, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China.
Ailiang ZengDepartment of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
Yan ShiDepartment of Neurosurgery, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China LLSnjmu@163.com shiyan9568@foxmail.com.
Liangsheng LuoDepartment of Neurosurgery, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China LLSnjmu@163.com shiyan9568@foxmail.com.ORCID 0000-0002-6091-1944
Nanjing Medical University · CNBrigham and Women's Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In recent years, many studies have reported on the abnormal expression and correlation of long non-coding RNAs (lncRNAs) in tumours. However, the accurate molecular mechanism of lncRNAs in glioma is still in its infancy. In the present study, we aimed to explore the molecular mechanism of small nucleolar RNA host gene 5 (SNHG5) in glioma progression. First, we found that SNHG5 expression was higher in glioma and was related to glioma glucose uptake, migration and invasion. Second, through a series of assays, we concluded that SNHG5 acts as a sponge for miR-205, which inhibits tumour growth in glioma by targeting E2F transcription factor 3 (E2F3). Third, using a xenograft mouse model, we demonstrated that SNHG5 regulates tumourigenesis

Indexed as

Gene Expression Regulation, NeoplasticAnimalsBiological TransportBrain NeoplasmsCarcinogenesisCell Line, TumorCell MovementCell ProliferationDisease ProgressionE2F3 Transcription FactorGliomaGlucoseHumansMaleMiceMice, NudeE2F3 protein, humanE2F3 Transcription FactorGlucoselong non-coding RNA SNHG5, humanMicroRNAsMIR205, humanRNA, Long NoncodingRNA, Small InterferingceRNAE2F3gliomalarge intervening non-coding RNASNHG5

Identifiers

PMID31292168
PMCPMC6639464
OpenAlexW2959068671

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.