Evidence map›Paper›PMID 31292162›Full record

ArticleCancer research2019

DNA-SWCNT Biosensors Allow Real-Time Monitoring of Therapeutic Responses in Pancreatic Ductal Adenocarcinoma.

Santanu Bhattacharya, Xun Gong, Enfeng Wang, Shamit K Dutta, Joseph R Caplette, Manki Son, Freddy T Nguyen, Michael S Strano, Debabrata Mukhopadhyay

Abstract read
In one paragraph

Article in Cancer research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
  2. Review
  3. Near-Infrared Fluorescent Single-Walled Carbon Nanotubes for Biosensing.Small (Weinheim an der Bergstrasse, Germany) · 2025
    Review
  4. Biosensing with Fluorescent Carbon Nanotubes.Angewandte Chemie (International ed. in English) · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Santanu BhattacharyaDepartment of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine and Science, Jacksonville, Florida.
Xun GongDepartment of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts.ORCID 0000-0003-4168-2768
Enfeng WangDepartment of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine and Science, Jacksonville, Florida.
Shamit K DuttaDepartment of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine and Science, Jacksonville, Florida.
Joseph R CapletteDepartment of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine and Science, Jacksonville, Florida.
Manki SonDepartment of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts.
Freddy T NguyenDepartment of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts.ORCID 0000-0003-0106-8114
Michael S StranoDepartment of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts.
Debabrata MukhopadhyayDepartment of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine and Science, Jacksonville, Florida. mukhopadhyay.debabrata@mayo.edu.
Jacksonville College · USMassachusetts Institute of Technology · US

Funding

Targeting Pancreatic Cancer Using Peptide Chemistry: From Bench to BedsideR01CA150190 · NCI · MAYO CLINIC ROCHESTER · PI MIERKE, DALE F, MUKHOPADHYAY, DEBABRATA · 2010 to 2021
$5.7M
Distinct Pathways of VPF/VEGF ReceptorsR01HL070567 · NHLBI · MAYO CLINIC ROCHESTER · PI MUKHOPADHYAY, DEBABRATA · 2002 to 2014
$4.7M
Regulatory Pathways and Role of VPF/VEGF in Renal CancerR01CA078383 · NCI · MAYO CLINIC ROCHESTER · PI MUKHOPADHYAY, DEBABRATA · 2004 to 2019
$4.5M
REGULATORY PATHWAYS AND ROLE OF VPF/VEGF IN RENAL CANCERR29CA078383 · NCI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI MUKHOPADHYAY, DEBABRATA · 1998 to 2002
$383k
NCI NIH HHS R01 CA078383NCI NIH HHS R01 CA150190NCI NIH HHS R29 CA078383NHLBI NIH HHS R01 HL070567
6 · The paper itself

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is a highly desmoplastic cancer with limited treatment options. There is an urgent need for tools that monitor therapeutic responses in real time. Drugs such as gemcitabine and irinotecan elicit their therapeutic effect in cancer cells by producing hydrogen peroxide (H

Indexed as

AnimalsAntimetabolites, AntineoplasticBiosensing TechniquesCarcinoma, Pancreatic DuctalDeoxycytidineDrug MonitoringFemaleGemcitabineHumansHydrogen PeroxideIrinotecanLuminescenceMice, SCIDNanotubes, CarbonPancreatic NeoplasmsSpectrum Analysis, RamanAntimetabolites, AntineoplasticDeoxycytidineGemcitabineHydrogen PeroxideIrinotecanNanotubes, Carbon

Identifiers

PMID31292162
PMCPMC6726513
OpenAlexW2959353112

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.