Evidence map›Paper›PMID 31292120›Full record

ArticleBMJ (Clinical research ed.)2019

Health outcomes of young children born to mothers who received 2009 pandemic H1N1 influenza vaccination during pregnancy: retrospective cohort study.

Laura K Walsh, Jessy Donelle, Linda Dodds, Steven Hawken, Kumanan Wilson, Eric I Benchimol, Pranesh Chakraborty, Astrid Guttmann, Jeffrey C Kwong, Noni E MacDonald and 6 more

Registry-linked trialOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ (Clinical research ed.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04579822 (Maternal and Fetal Outcomes Following Influenza Vaccination in Pregnancy), which is not on this map. Cited by 22 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 3 pooled it
5.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04579822 unknown statusnot on this mapstarted 2020, after this paper: background citation

Maternal and Fetal Outcomes Following Influenza Vaccination in Pregnancy

TypeobservationalSponsorSungkyunkwan UniversityRan2020 to 2022Enrolled300,000ConditionsPregnancy Related, Influenza Virus Vaccine Adverse ReactionArmsinfluenza vaccine
3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 3 syntheses or guidelines pooled it, 45 citations in OpenAlex.

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  5. Association Between COVID-19 Vaccination During Pregnancy and Safety Among Infants.Journal of the Pediatric Infectious Diseases Society · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 2 countries.

Laura K WalshBetter Outcomes Registry & Network, Ottawa, ON, Canada.
Jessy DonelleICES, Toronto, ON, Canada.
Linda DoddsDalhousie University, Halifax, NS, Canada.
Steven HawkenUniversity of Ottawa, Ottawa, ON, Canada.
Kumanan WilsonUniversity of Ottawa, Ottawa, ON, Canada.
Eric I BenchimolUniversity of Ottawa, Ottawa, ON, Canada.
Pranesh ChakrabortyUniversity of Ottawa, Ottawa, ON, Canada.
Astrid GuttmannICES, Toronto, ON, Canada.
Jeffrey C KwongICES, Toronto, ON, Canada.
Noni E MacDonaldDalhousie University, Halifax, NS, Canada.
Justin R OrtizUniversity of Maryland School of Medicine, Baltimore, MD, USA.
Ann E SpragueBetter Outcomes Registry & Network, Ottawa, ON, Canada.
Karina A TopDalhousie University, Halifax, NS, Canada.
Mark C WalkerBetter Outcomes Registry & Network, Ottawa, ON, Canada.
Shi Wu WenUniversity of Ottawa, Ottawa, ON, Canada.
Deshayne B FellUniversity of Ottawa, Ottawa, ON, Canada dfell@cheo.on.ca.ORCID 0000-0002-5548-3228
University of Ottawa · CADalhousie University · CAUniversity of Toronto · CAUniversity of Maryland, Baltimore · US

Funding

CIHR
6 · The paper itself

Abstract

objectiveTo determine whether any association exists between exposure to 2009 pandemic H1N1 (pH1N1) influenza vaccination during pregnancy and negative health outcomes in early childhood.

designRetrospective cohort study.

settingPopulation based birth registry linked with health administrative databases in the province of Ontario, Canada.

participantsAll live births from November 2009 through October 2010 (n=104 249) were included, and children were followed until 5 years of age to ascertain study outcomes.

main outcome measuresRates of immune related (infectious diseases, asthma), non-immune related (neoplasms, sensory disorders), and non-specific morbidity outcomes (urgent or inpatient health services use, pediatric complex chronic conditions) were evaluated from birth to 5 years of age; under-5 childhood mortality was also assessed. Propensity score weighting was used to adjust hazard ratios, incidence rate ratios, and risk ratios for potential confounding.

resultsOf 104 249 live births, 31 295 (30%) were exposed to pH1N1 influenza vaccination in utero. No significant associations were found with upper or lower respiratory infections, otitis media, any infectious diseases, neoplasms, sensory disorders, urgent and inpatient health services use, pediatric complex chronic conditions, or mortality. A weak association was observed between prenatal pH1N1 vaccination and increased risk of asthma (adjusted hazard ratio 1.05, 95% confidence interval 1.02 to 1.09) and decreased rates of gastrointestinal infections (adjusted incidence rate ratio 0.94, 0.91 to 0.98). These results were unchanged in sensitivity analyses accounting for any potential differential healthcare seeking behavior or access between exposure groups.

conclusionsNo associations were observed between exposure to pH1N1 influenza vaccine during pregnancy and most five year pediatric health outcomes. Residual confounding may explain the small associations observed with increased asthma and reduced gastrointestinal infections. These outcomes should be assessed in future studies.

Indexed as

Child HealthInfluenza A Virus, H1N1 SubtypePrenatal Exposure Delayed EffectsAdultAsthmaChild, PreschoolFemaleGastrointestinal DiseasesHumansInfantInfant, NewbornInfectionsInfluenza, HumanInfluenza VaccinesOntarioPandemicsInfluenza Vaccines

Identifiers

PMID31292120
PMCPMC6614795
OpenAlexW2959068009

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.