ArticleBiological psychiatry2019
Neurobiological Markers of Resilience to Depression Following Childhood Maltreatment: The Role of Neural Circuits Supporting the Cognitive Control of Emotion.
Article in Biological psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 76 papers, 3 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
76 citing papers in PubMed, 3 syntheses or guidelines pooled it, 147 citations in OpenAlex.
- Annual Research Review: What processes are dysregulated among emotionally dysregulated youth? - a systematic review.Journal of child psychology and psychiatry, and allied disciplines · 2025Pooled it
- Unpacking reappraisal: a systematic review of fMRI studies of distancing and reinterpretation.Social cognitive and affective neuroscience · 2023Pooled it
- Emotion regulation as mediator between childhood adversity and psychopathology: A meta-analysis.Clinical psychology review · 2022Pooled it
- Family-based care buffers the stress sensitizing effect of early deprivation on executive functioning difficulties in adolescence.Child development · 2023Trial
- Longitudinal Associations Between Resilience, Emotion Regulation and Mental Health in Adolescents.The Psychiatric quarterly · 2026Article
- Differential adolescent neurodevelopment of emotion processing across internalizing psychopathology and childhood adversity.Developmental cognitive neuroscience · 2026Article
- The indirect association between psychological resilience and prosocial behavior through cognitive reappraisal in Chinese college students.Frontiers in psychology · 2026Article
- Adverse Childhood Experiences Underlie Race-Related Differences in Neural Reactivity to Stress.Behavioural neurology · 2026Article
- The neurobiological effects of childhood maltreatment on brain structure, function, and attachment.European archives of psychiatry and clinical neuroscience · 2025Review
- Social support, spirituality, and executive functions: An event-related potential (ERP) study of neural mechanisms of cultural protective factors in American Indians (AIs).The American psychologist · 2025Article
- Modification of Brain Connectome on Association Between Adverse Childhood Experiences and Development of Mental Disorders in Preadolescence.JAMA network open · 2025Article
- Neural activation during processing of emotional faces as a function of resilience in adolescents.European child & adolescent psychiatry · 2025Article
- The role of caregiver emotion regulation in youth mental health during the COVID-19 pandemic: A longitudinal study.Development and psychopathology · 2025Article
- Maternal Depressive Symptoms and Risk for Childhood Depression: Role of Executive Functions.Journal of the American Academy of Child and Adolescent Psychiatry · 2025Observational
- Genetic risk-dependent brain markers of resilience to childhood Trauma.Nature communications · 2025Article
- Narrative Review: A Neurobiological Perspective on Resilience in Youth.JAACAP open · 2025Review
- The effects of adverse life events on brain development in the ABCD study®: a propensity-weighted analysis.Molecular psychiatry · 2025Article
- The mediating role of family functioning between childhood adversity and adult Health- related risk behaviors: a moderated mediation analysis of generational gap in Chinese migrant workers.Population health metrics · 2025Article
- Review
- Fluctuations in emotion regulation as a mechanism linking stress and internalizing psychopathology among adolescents: An intensive longitudinal study.Behaviour research and therapy · 2024Article
16 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issuedErratum.2020
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundChildhood adversity is strongly linked to negative mental health outcomes, including depression and anxiety. Leveraging cognitive neuroscience to identify mechanisms that contribute to resilience in children with a history of maltreatment may provide viable intervention targets for the treatment or prevention of psychopathology. We present a conceptual model of a potential neurobiological mechanism of resilience to depression and anxiety following childhood adversity. Specifically, we argue that neural circuits underlying the cognitive control of emotion may promote resilience, wherein a child's ability to recruit the frontoparietal control network to modulate amygdala reactivity to negative emotional cues-such as during cognitive reappraisal-buffers risk for internalizing symptoms following exposure to adversity.
methodsWe provide preliminary support for this model of resilience in a longitudinal sample of 151 participants 8 to 17 years of age with (n = 79) and without (n = 72) a history of childhood maltreatment who completed a cognitive reappraisal task while undergoing functional magnetic resonance imaging.
resultsAmong maltreated youths, those who were better able to recruit prefrontal control regions and modulate amygdala reactivity during reappraisal exhibited lower risk for depression over time. By contrast, no association was observed between neural functioning during reappraisal and depression among youths without a history of maltreatment.
conclusionsThese preliminary findings support the hypothesis that children who are better able to regulate emotion through recruitment of the frontoparietal network exhibit greater resilience to depression following childhood maltreatment. Interventions targeting cognitive reappraisal and other cognitive emotion regulation strategies may have potential for reducing vulnerability to depression among children exposed to adversity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.