Evidence map›Paper›PMID 31291909›Full record

ArticleBMC nephrology2019

Clinical predictors of renal non-recovery in acute respiratory distress syndrome.

Anupol Panitchote, Omar Mehkri, Andrei Hastings, Tarik Hanane, Sevag Demirjian, Heather Torbic, Eduardo Mireles-Cabodevila, Sudhir Krishnan, Abhijit Duggal

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC nephrology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Incidence, Outcomes, and Predictors of Subphenotypes of Acute Kidney Injury among Acute Respiratory Distress Syndrome Patients: A Prospective Observational Study.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2023
    Article
  6. Article
  7. Article
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  9. Review
  10. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Anupol PanitchoteDepartment of Critical Care, Respiratory Institute, Cleveland Clinic, Cleveland, OH, USA.
Omar MehkriDepartment of Critical Care, Respiratory Institute, Cleveland Clinic, Cleveland, OH, USA.
Andrei HastingsDepartment of Critical Care, Respiratory Institute, Cleveland Clinic, Cleveland, OH, USA.
Tarik HananeDepartment of Critical Care, Respiratory Institute, Cleveland Clinic, Cleveland, OH, USA.
Sevag DemirjianDepartment of Nephrology, Cleveland Clinic, Cleveland, OH, USA.
Heather TorbicDepartment of Pharmacology, Cleveland Clinic, Cleveland, OH, USA.
Eduardo Mireles-CabodevilaDepartment of Critical Care, Respiratory Institute, Cleveland Clinic, Cleveland, OH, USA.
Sudhir KrishnanDepartment of Critical Care, Respiratory Institute, Cleveland Clinic, Cleveland, OH, USA.
Abhijit DuggalDepartment of Critical Care, Respiratory Institute, Cleveland Clinic, Cleveland, OH, USA. duggala2@ccf.org.
Cleveland Clinic · USKhon Kaen University · TH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAcute kidney injury (AKI) is the most common extra-pulmonary organ failure in acute respiratory distress syndrome (ARDS). Renal recovery after AKI is determined by several factors. The objective of this study was to determine the predictors of renal non-recovery in ARDS patients.

methodsA single center retrospective cohort study of patients with AKI after onset of ARDS. Patients with preexisting chronic kidney disease or intensive care unit stay < 24 h were excluded. AKI staging was defined according to the Kidney Disease Improving Global Outcomes (KDIGO) 2012 guidelines. Renal non-recovery was defined as death, dialysis dependence, serum creatinine ≥1.5 times the baseline, or urine output < 0.5 mL/kg/h more than 6 h.

resultsOf the 244 patients that met study criteria, 60 (24.6%) had stage I AKI, 66 (27%) had stage II AKI, and 118 (48.4%) had stage III AKI. Of those, 148 (60.7%) patients had renal non-recovery. On multivariable analysis, factors associated with renal non-recovery were a higher stage of AKI (odds ratio [OR] stage II 5.71, 95% confidence interval [CI] 2.17-14.98; OR stage III 45.85, 95% CI 16.27-129.2), delay in the onset of AKI (OR 1.12, 95% CI 1.03-1.21), history of malignancy (OR 4.02, 95% CI 1.59-10.15), septic shock (OR 3.2, 95% CI 1.52-6.76), and a higher tidal volume on day 1-3 of ARDS (OR 1.41, 95% CI 1.05-1.90). Subgroup analysis of survival at day 28 of ARDS also found that higher severity of AKI (OR stage II 8.17, 95% CI 0.84-79.91; OR stage III 111.67, 95% CI 12.69-982.91), delayed onset of AKI (OR 1.12, 95% CI 1.02-1.23), and active malignancy (OR 6.55, 95% CI 1.34-32.04) were significant predictors of renal non-recovery.

conclusionsA higher stage of AKI, delayed onset of AKI, a history of malignancy, septic shock, and a higher tidal volume on day 1-3 of ARDS predicted renal non-recovery in ARDS patients. Among survivors, a higher stage of AKI, delayed onset of AKI, and a history of malignancy were associated with renal non-recovery.

Indexed as

Acute Kidney InjuryAdultCohort StudiesCreatinineFemaleHumansMaleMiddle AgedRenal DialysisRespiratory Distress SyndromeRetrospective StudiesCreatinineAcute kidney injuryAcute respiratory distress syndromeMechanical ventilationPredictorRenal recoverySeptic shock

Identifiers

PMID31291909
PMCPMC6617675
OpenAlexW2961004720

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.