Evidence map›Paper›PMID 31291904›Full record

Observational studyBMC nephrology2019

Time-varying serum albumin levels and all-cause mortality in prevalent peritoneal dialysis patients: a 5-year observational study.

Na Hao, Ben-Chung Cheng, Hong-Tao Yang, Chien-Hsing Wu, Yang-Yang Lei, Mei-Chen Chao, Pei-Ying Wang, Li-Chueh Kuo, Sin-Hua Moi, Cheng-Hong Yang and 1 more

Abstract readObservational Study
In one paragraph

Observational study in BMC nephrology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

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  12. Associations between liver function parameters and poor clinical outcomes in peritoneal dialysis patients.Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Na HaoDivision of Nephrology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, 88 Chang Ling Rd, Xi Qing District, Tianjin, China.
Ben-Chung ChengDivision of Nephrology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, No.123 Dapi Road, Niaosong District, Kaohsiung City, 83301, Taiwan.
Hong-Tao YangDivision of Nephrology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, 88 Chang Ling Rd, Xi Qing District, Tianjin, China.
Chien-Hsing WuDivision of Nephrology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, No.123 Dapi Road, Niaosong District, Kaohsiung City, 83301, Taiwan.
Yang-Yang LeiDivision of Nephrology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, 88 Chang Ling Rd, Xi Qing District, Tianjin, China.
Mei-Chen ChaoPeritoneal Dialysis Center, Division of Nephrology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, No.123 Dapi Road, Niaosong District, Kaohsiung City, 83301, Taiwan.
Pei-Ying WangPeritoneal Dialysis Center, Division of Nephrology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, No.123 Dapi Road, Niaosong District, Kaohsiung City, 83301, Taiwan.
Li-Chueh KuoPeritoneal Dialysis Center, Division of Nephrology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, No.123 Dapi Road, Niaosong District, Kaohsiung City, 83301, Taiwan.
Sin-Hua MoiDepartment of Electronic Engineering, National Kaohsiung University of Science and Technology, No. 415 Jiangong Road, Sanmin District, Kaohsiung City, 80778, Taiwan.
Cheng-Hong YangDepartment of Electronic Engineering, National Kaohsiung University of Science and Technology, No. 415 Jiangong Road, Sanmin District, Kaohsiung City, 80778, Taiwan.
Jin-Bor ChenDivision of Nephrology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, No.123 Dapi Road, Niaosong District, Kaohsiung City, 83301, Taiwan. chenjb1019@gmail.com.ORCID 0000-0003-4007-1455

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn this study, we investigated the association of time-varying serum albumin levels with mortality over a 5-year period in one cohort of patients undergoing long-term peritoneal dialysis (PD) therapy.

methodsThe participants in this study enrolled 302 patients who underwent long-term PD at a single PD center in Taiwan. We reviewed medical records from 2011 to 2015 retrospectively. Time-averaged albumin level and serum albumin reach rate (defined as the percentage of serum albumin measurements that reached ≥3.5 g/dL) were applied as the predictor variables in the first 2 years (2011-2012). All-cause mortality was used as the outcome variable in the subsequent 3 years (2013-2015). Hazard function of all-cause mortality in the study participants was examined by using Cox proportional hazard regression models .

resultsPatients with different albumin reach rates (75-< 100%, 50-< 75%, 1-< 50%) did not exhibit a significantly increased risk for all-cause mortality. Patients with a 0% albumin reach rate exhibited a significantly increased risk for all-cause mortality (hazard ratio [HR] 7.59, 95% confidence interval [CI], 2.38-24.21) by fully adjusted analysis. Patients with time-averaged albumin levels of < 3.5 g/dL (HR 15.49, 95% CI 1.74-137.72) exhibited a higher risk for all-cause mortality than those with serum albumin levels ≥4.0 g/dL.

conclusionsThis study demonstrated that higher serum albumin reach rates and higher time-averaged serum albumin levels are associated with a lower mortality rate over a 5-year period among patients undergoing long-term PD.

Indexed as

Peritoneal DialysisAdultAgedCause of DeathFemaleHumansKidney Failure, ChronicMaleMiddle AgedRetrospective StudiesSerum AlbuminTime FactorsSerum AlbuminAlbuminMortalityPeritoneal dialysis

Identifiers

PMID31291904
PMCPMC6617609

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.