ArticleThe journal of headache and pain2019
Diffusion tensor imaging in middle-aged headache sufferers in the general population: a cross-sectional population-based imaging study in the Nord-Trøndelag health study (HUNT-MRI).
Article in The journal of headache and pain, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Microstructural white matter alterations associated with migraine headaches: a systematic review of diffusion tensor imaging studies.Brain imaging and behavior · 2022Pooled it
- Hallmarks of primary headache: part 2- Tension-type headache.The journal of headache and pain · 2025Review
- Article
- Review
- Increased MRI-based Brain Age in chronic migraine patients.The journal of headache and pain · 2023Article
- Current Knowledge about Headaches Attributed to Ischemic Stroke: Changes from Structure to Function.Brain sciences · 2023Review
- Diffusion Tensor and Kurtosis Imaging Findings the First Year following Mild Traumatic Brain Injury.Journal of neurotrauma · 2023Article
- Intrinsic Brain Functional Activity Abnormalities in Episodic Tension-Type Headache.Neural plasticity · 2023Article
- Structural brain changes in patients with persistent headache after COVID-19 resolution.Journal of neurology · 2023Article
- Acute Diffusion Tensor and Kurtosis Imaging and Outcome following Mild Traumatic Brain Injury.Journal of neurotrauma · 2021Article
- Alternative Microstructural Measures to Complement Diffusion Tensor Imaging in Migraine Studies with Standard MRI Acquisition.Brain sciences · 2020Article
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5 authors.
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Abstract
backgroundSeveral studies have investigated white matter with diffusion tensor imaging (DTI) in those suffering from headache, but so far only in clinic based samples and with conflicting results.
methodsIn the present study, 1006 individuals (50-66 years) from the general population (Nord-Trøndelag Health Study) participated in an imaging study of the head at 1.5 T (HUNT-MRI). Hundred and ninety-six individuals were excluded because of errors in the data acquisition or brain pathology. Two hundred and forty-six of the remaining participants reported suffering from headache (69 from migraine and 76 from tension-type headache) the year prior to the scanning. DTI data were analysed with Tract-Based Spatial Statistics and automated tractography. Type of headache, frequency of attacks and evolution of headache were investigated for an association with white matter fractional anisotropy (FA), mean diffusivity (MD), axonal diffusivity (AD), radial diffusivity (RD) and tract volume. Correction for various demographical and clinical variables were performed.
resultsHeadache sufferers had widespread higher white matter MD, AD and RD compared to headache free individuals (n = 277). The effect sizes were mostly small with the largest seen in those with middle-age onset headache, who also had lower white matter FA. There were no associations between white matter microstructure and attack frequency or type of headache.
conclusionMiddle-age onset headache may be related to a widespread process in the white matter leading to altered microstructure.
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