SynthesisBMC geriatrics2019
What are the most effective interventions to improve physical performance in pre-frail and frail adults? A systematic review of randomised control trials.
Synthesis in BMC geriatrics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 73 papers, 8 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effectiveness of Precision Nursing Intervention Program on Cognitive Function、Sleep Quality and Emotional State of Frail Female Elderly in the Community
Application of the Transtheoretical Model to Physical Activity and Health-related Quality of Life Among the Frailty of the Community Elderly
Multicomponent Exercise and Nutrition Based Frailty Intervention in Postoperative Hip Fracture Inpatients
Who cites it
73 citing papers in PubMed, 8 syntheses or guidelines pooled it, 165 citations in OpenAlex.
- Frailty assessment and effect of physical activity interventions in older adults: a scoping review, meta-analysis, and meta-regression.BMC geriatrics · 2026Pooled it
- Evidence on non-pharmacological interventions for preventing or reversing physical frailty in community-dwelling older adults aged over 50 years: overview of systematic reviews.BMC geriatrics · 2025Pooled it
- Factors associated with frailty in older people: an umbrella review.BMC geriatrics · 2024Pooled it
- Community-based exercises improve health status in pre-frail older adults: A systematic review with meta-analysis.BMC geriatrics · 2024Pooled it
- Physical-activity interventions to reduce fear of falling in frail and pre-frail older adults: a systematic review of randomized controlled trials.European geriatric medicine · 2024Pooled it
- The prevalence and prognostic value of frailty screening measures in patients undergoing surgery for colorectal cancer: observations from a systematic review.BMC geriatrics · 2022Pooled it
- Volunteer-led physical activity interventions to improve health outcomes for community-dwelling older people: a systematic review.Aging clinical and experimental research · 2021Pooled it
- The impact of interventions on management of frailty in hospitalized frail older adults: a systematic review and meta-analysis.BMC geriatrics · 2020Pooled it
- The effect of low-dose aspirin on reversing frailty status in older prefrail and frail adults: a secondary analysis of the ASPREE randomised clinical trial.Age and ageing · 2025Trial
- Trial
- The Effectiveness of Frailty Intervention for Older Patients with Frailty during Hospitalization.The journal of nutrition, health & aging · 2023Trial
- Evaluating the feasibility of a remote-based training program supported by information and communications technology in the older adults living at home.BMC geriatrics · 2022Trial
- Resilience is associated with frailty and older age in hospitalised patients.BMC geriatrics · 2022Trial
- Associations between frailty, physical performance, and renal biomarkers in older people with advanced chronic kidney disease.European geriatric medicine · 2021Trial
- Validation and refinement of a biomarker panel for frailty assessment and prediction of muscle weakness in older adults.npj aging · 2026Article
- Randomized Controlled Trial of Individualized Intervention for Frailty Reversal in Older Patients With Nondialysis CKD.Kidney international reports · 2026Article
- Inflammaging and Sarcopenia as Interconnected Hallmarks of Aging: Integrative Roles of Bioactive Compounds and Lifestyle Interventions.Nutrients · 2026Review
- Impact of the family cohesion-centered frailty intervention on older gastric cancer patients: a non-randomized controlled trial.BMC medicine · 2026Article
- Performance-Based and Self-Reported Frailty in Older Adults with or Without Fibromyalgia.European journal of investigation in health, psychology and education · 2026Article
- Incidental Lifestyle Physical Activity and Its Relationships With Overall Frailty and Frailty Domains in Community-Dwelling Older Japanese.Geriatrics & gerontology international · 2026Article
13 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWith life expectancy continuing to rise in the United Kingdom there is an increasing public health focus on the maintenance of physical independence among all older adults. Identifying interventions that improve physical outcomes in pre-frail and frail older adults is imperative.
methodsA systematic review of the literature 2000 to 2017 following PRISMA guidelines and registered with PROSPERO (no. CRD42016045325).
resultsTen RCT trials fulfilled selection criteria and quality appraisal. The study quality was moderate to good. Interventions included physical activity; nutrition, physical activity combined with nutrition. Interventions that incorporated one or more physical activity components significantly improved physical outcomes in pre-frail and/or frail older adults.
conclusionsPhysical activity interventions are key to maintaining independence in pre-frail and frail older adults. A lack of consensus regarding the definition of frailty, and an absence of core measures to assess this means any attempt to create an optimal intervention will be impeded. This absence may ultimately impact on the ability of older and frail adults to live well and for longer in the community.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.