ArticleTherapeutic advances in respiratory disease
The impact of comorbidities on mortality among men and women with COPD: report from the OLIN COPD study.
Article in Therapeutic advances in respiratory disease. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Prevalence of Pulmonary Embolism and Deep Venous Thromboembolism in Patients With Acute Exacerbation of Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-Analysis.Frontiers in cardiovascular medicine · 2022Pooled it
- Sex differences among inpatients with AECOPD in a tertiary hospital during the COVID-19 pandemic.BMC pulmonary medicine · 2026Article
- Sex Differences and Survival Among COPD Patients in France: The Palomb Cohort.International journal of chronic obstructive pulmonary disease · 2026Observational
- Gender-Based Differences in COPD Patients with Type 2 Respiratory Failure-Impact on Clinical Practice.Medicina (Kaunas, Lithuania) · 2025Observational
- The status and influencing factors of lung ventilation function in employees exposed to dust in enterprises of the XPCC, China.Frontiers in public health · 2024Article
- Sex differences in comorbidities and mortality risk among patients with chronic obstructive pulmonary disease: a study based on NHANES data.BMC pulmonary medicine · 2023Article
- A Real-Life Study of Combined Treatment with Long-Term Non-Invasive Ventilation and High Flow Nasal Cannula in Patients with End-Stage Chronic Obstructive Lung Disease.Journal of clinical medicine · 2023Article
- Comorbid Heart Disease in Patients with COPD is Associated with Increased Hospitalization and Mortality - A 15-Year Follow-Up.International journal of chronic obstructive pulmonary disease · 2023Article
- Machine learning reveals sex differences in clinical features of acute exacerbation of chronic obstructive pulmonary disease: A multicenter cross-sectional study.Frontiers in medicine · 2023Article
- Cardiovascular predictors of mortality and exacerbations in patients with COPD.Scientific reports · 2022Article
- The Effect of Cardiovascular Comorbidities on Women Compared to Men: Longitudinal Retrospective Analysis.JMIR cardio · 2021Article
- Chronic obstructive pulmonary disease as a risk factor in primary care: a Canadian retrospective cohort study.NPJ primary care respiratory medicine · 2021Article
- Multimorbidity clusters in patients with chronic obstructive airway diseases in the EpiChron Cohort.Scientific reports · 2021Observational
- Prevalence of different comorbidities in chronic obstructive pulmonary disease among Shahrekord PERSIAN cohort study in southwest Iran.Scientific reports · 2021Article
- Chronic hypoxaemia and gender status modulate adiponectin plasmatic level and its multimer proportion in severe COPD patients: new endotypic presentation?BMC pulmonary medicine · 2020Article
- Airways diseases: asthma, COPD and chronic cough highlights from the European Respiratory Society Annual Congress 2018.Journal of thoracic disease · 2018Article
- All-cause and cause-specific mortality by spirometric pattern and sex - a population-based cohort study.Therapeutic advances in respiratory diseaseArticle
- Mortality among Canadian population with multimorbidity: A retrospective cohort study.Journal of multimorbidity and comorbidityArticle
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundComorbidities probably contribute to the increased mortality observed among subjects with chronic obstructive pulmonary disease (COPD), but sex differences in the prognostic impact of comorbidities have rarely been evaluated in population-based studies. The aim of this study was to evaluate the impact of common comorbidities, cardiovascular disease (CVD), diabetes mellitus (DM), and anxiety/depression (A/D), on mortality among men and women with and without airway obstruction in a population-based study.
methodsAll subjects with airway obstruction [forced expiratory volume in 1 second (FEV
resultsIn COPD, the prevalence of CVD and DM was higher in men, whereas the prevalence of A/D was higher in women. The cumulative mortality was significantly higher in COPD than NLF, and higher in men than women in both groups. Among women with COPD, CVD and A/D but not DM increased the risk of death independent of age, body mass index, smoking habits, and disease severity, whereas among men DM and A/D but not CVD increased the risk for death. When the LLN criterion was applied, the pattern was similar.
conclusionThere were sex-dependent differences regarding the impact of comorbidities on prognosis in COPD. Even though the prevalence of CVD was higher in men, the impact of CVD on mortality was higher in women, and despite higher prevalence of A/D in women, the impact on mortality was similar in both sexes.
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