Evidence map›Paper›PMID 31291329›Full record

ArticlePloS one2019

Outcome of inadvertent high dose BCG administration in newborns at a tertiary care hospital, Karachi- Case series.

Sonia Qureshi, Khalil Ahmad, Paras Fatima, Rabia M Hassan, Farheen Sherali, Naureen Lalani, Fyezah Jehan, Syed Asad Ali, Farah Naz Qamar

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Sonia QureshiDepartment of Pediatrics and Child Health, Aga Khan University, Karachi, Pakistan.
Khalil AhmadDepartment of Pediatrics and Child Health, Aga Khan University, Karachi, Pakistan.
Paras FatimaMedical Student, Aga Khan University, Karachi, Pakistan.
Rabia M HassanDepartment of Pediatrics and Child Health, Aga Khan University, Karachi, Pakistan.
Farheen SheraliDepartment of Pediatrics and Child Health, Aga Khan University, Karachi, Pakistan.
Naureen LalaniDepartment of Pediatrics and Child Health, Aga Khan University, Karachi, Pakistan.
Fyezah JehanDepartment of Pediatrics and Child Health, Aga Khan University, Karachi, Pakistan.
Syed Asad AliDepartment of Pediatrics and Child Health, Aga Khan University, Karachi, Pakistan.
Farah Naz QamarDepartment of Pediatrics and Child Health, Aga Khan University, Karachi, Pakistan.ORCID 0000-0002-1099-2483
Aga Khan University · PK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bacillus Calmette-Guérin (BCG) vaccine is given to newborns soon after birth. BCG vaccine overdose has been rarely reported. Here we report the outcome of newborns who accidently received high dose BCG at a tertiary care hospital, Karachi. We reviewed records of 26 newborns, who accidentally received intradermal high dose BCG, used for the treatment of urinary bladder cancers and 80 times higher dose than the BCG used for routine vaccination. The incident happened from 14-16th April, 2016 at Aga Khan University Hospital, Karachi. Analysis was carried out using SPSS. A total of 23/26(88.5%) newborns were followed for atleast 3 months and 11/26 (42.3%) were followed for atleast one year. 13/26 (50%) were male. All 26 patients were prescribed isoniazid and rifampicin for 3 months. 3/26 (11.5%) were lost to follow-up before completion of anti-tuberculous drugs (ATT). Lesions at the BCG site were observed in 16/26 (61.5%) infants, of which 15 (93.8%) had a papule, 3 (18.8%) developed a pustule, 3 (18.8%) had skin induration and 2 (12.5%) had skin erythema. Axillary lymphadenopathy was observed in 1/26 (3.8%) patient. Coagulation was deranged in 3/26 (11.5%) of babies. Intracranial bleeding was observed in 1/26 (3.8%) case. Localized skin lesions were the most common adverse events. None of them developed clinical tuberculosis. Chemoprophylaxis for inadvertent high dose BCG administration should be given for atleast 3 months. Furthermore, vigilant follow-up, transparency and disclosure are the vital steps in the management of any medical error.

Indexed as

Dose-Response Relationship, DrugAntitubercular AgentsBCG VaccineDrug CombinationsFemaleHumansInfantInfant, NewbornIsoniazidMaleMycobacterium bovisPakistanRifampinTertiary Care CentersTuberculosisVaccinationAntitubercular AgentsBCG VaccineDrug CombinationsIsoniazidRifampin

Identifiers

PMID31291329
PMCPMC6619743
OpenAlexW2956394890

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.