ArticleeLife2019
Defective AMH signaling disrupts GnRH neuron development and function and contributes to hypogonadotropic hypogonadism.
Open access · goldAbstract read
In one paragraph
Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 3 pooled it
10.5field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed, 3 syntheses or guidelines pooled it, 73 citations in OpenAlex.
- Metabolic profiling of human follicular fluid to unravel the pathways involved in polycystic ovary syndrome - a systematic review.Reviews in endocrine & metabolic disorders · 2026Pooled it
- The best ovarian reserve marker to predict ovarian response following controlled ovarian hyperstimulation: a systematic review and meta-analysis.Systematic reviews · 2024Pooled it
- Clinical Utility of Anti-Mullerian Hormone in Pediatrics.The Journal of clinical endocrinology and metabolism · 2022Pooled it
- Genetics of Idiopathic Hypogonadotropic HypogonadismJournal of clinical research in pediatric endocrinology · 2026Review
- Polyendocrine metabolic ovarian syndrome (PMOS)/polycystic ovary syndrome (PCOS): current and future trends.The Journal of clinical investigation · 2026Review
- Molecular mechanisms and multi-organ regulatory roles of anti-Müllerian hormone in female reproduction.Communications biology · 2026Review
- Nanoplastics Impair GnRH Neuron Migration and Neuroendocrine Function: Emerging Players in the Pathogenesis of Reproductive Disorders.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- A Novel Steroidogenic Action of Anti-Müllerian Hormone in Teleosts: Evidence from the European Sea Bass Male (International journal of molecular sciences · 2025Article
- POLYCYSTIC OVARY SYNDROME: ORIGINS AND IMPLICATIONS: Gestational anti-Müllerian hormone and testosterone excess combined with maternal adiposity program for polycystic ovary syndrome.Reproduction (Cambridge, England) · 2025Review
- PROKR2 mutations and SPRY4 variants with uncertain significance in a Kallmann syndrome family: Incomplete penetrance.Global medical genetics · 2025Article
- Anti-Müllerian hormone signalling sustains circadian homeostasis in zebrafish.Nature communications · 2025Article
- Effect of circulating anti-Mullerian hormone on the reproductive potential of gilts.Frontiers in veterinary science · 2025Article
- Neuroendocrine modulation by metamizole and indomethacin: investigating the impact on neuronal markers and GnRH release.Endocrine · 2024Article
- Comparison of ovarian mRNA expression levels in wild and hatchery-produced greater amberjack Seriola dumerili.Scientific reports · 2024Article
- Genetic insights into the complexity of premature ovarian insufficiency.Reproductive biology and endocrinology : RB&E · 2024Review
- Mechanism of elevated LH/FSH ratio in lean PCOS revisited: a path analysis.Scientific reports · 2024Article
- Puberty Blocker and Aging Impact on Testicular Cell States and Function.bioRxiv : the preprint server for biology · 2024Article
- Obesity-Related Hypogonadism in Women.Endocrine reviews · 2024Review
- Anti-Müllerian Hormone: A Molecular Key to Unlocking Polycystic Ovary Syndrome?Seminars in reproductive medicine · 2024Review
- Anti-Müllerian hormone: biology and role in endocrinology and cancers.Frontiers in endocrinology · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
20 authors at 5 institutions in 4 countries.
Samuel Andrew MaloneJean-Pierre Aubert Research Center (JPArc), Laboratory of Development and Plasticity of the Neuroendocrine Brain, Inserm, UMR-S 1172, Lille, France.ORCID 0000-0002-6824-6854
Georgios E PapadakisFaculty of Biology and Medicine, Service of Endocrinology, Diabetology and Metabolism, University Hospital, Lausanne, Switzerland.
Andrea MessinaFaculty of Biology and Medicine, Service of Endocrinology, Diabetology and Metabolism, University Hospital, Lausanne, Switzerland.
Nour El Houda MimouniJean-Pierre Aubert Research Center (JPArc), Laboratory of Development and Plasticity of the Neuroendocrine Brain, Inserm, UMR-S 1172, Lille, France.
Sara TrovaJean-Pierre Aubert Research Center (JPArc), Laboratory of Development and Plasticity of the Neuroendocrine Brain, Inserm, UMR-S 1172, Lille, France.
Monica ImbernonJean-Pierre Aubert Research Center (JPArc), Laboratory of Development and Plasticity of the Neuroendocrine Brain, Inserm, UMR-S 1172, Lille, France.
Cecile AlletJean-Pierre Aubert Research Center (JPArc), Laboratory of Development and Plasticity of the Neuroendocrine Brain, Inserm, UMR-S 1172, Lille, France.
Irene CiminoJean-Pierre Aubert Research Center (JPArc), Laboratory of Development and Plasticity of the Neuroendocrine Brain, Inserm, UMR-S 1172, Lille, France.
James AciernoFaculty of Biology and Medicine, Service of Endocrinology, Diabetology and Metabolism, University Hospital, Lausanne, Switzerland.
Daniele CassatellaFaculty of Biology and Medicine, Service of Endocrinology, Diabetology and Metabolism, University Hospital, Lausanne, Switzerland.
Cheng XuFaculty of Biology and Medicine, Service of Endocrinology, Diabetology and Metabolism, University Hospital, Lausanne, Switzerland.
Richard QuintonInstitute of Genetic Medicine, University of Newcastle-upon-Tyne, Newcastle-upon-Tyne, United Kingdom.
Gabor SzinnaiPediatric Endocrinology and Diabetology, University of Basel Children's Hospital, Basel, Switzerland.
Pascal PignyCHU Lille, Laboratoire de Biochimie et Hormonologie, Centre de Biologie Pathologie, Lille, France.
Lur Alonso-CotchicoDepartament de Química, Universitat Autònoma de Barcelona, Bellaterra, Spain.
Laura MasgrauDepartament de Química, Universitat Autònoma de Barcelona, Bellaterra, Spain.
Jean-Didier MaréchalDepartament de Química, Universitat Autònoma de Barcelona, Bellaterra, Spain.
Vincent PrevotJean-Pierre Aubert Research Center (JPArc), Laboratory of Development and Plasticity of the Neuroendocrine Brain, Inserm, UMR-S 1172, Lille, France.ORCID 0000-0001-7185-3615
Nelly PitteloudFaculty of Biology and Medicine, Service of Endocrinology, Diabetology and Metabolism, University Hospital, Lausanne, Switzerland.
Paolo GiacobiniJean-Pierre Aubert Research Center (JPArc), Laboratory of Development and Plasticity of the Neuroendocrine Brain, Inserm, UMR-S 1172, Lille, France.ORCID 0000-0002-3075-1441
Inserm · FRUniversitat Autònoma de Barcelona · ESCentre Hospitalier Universitaire de Lille · FRNewcastle University · GBUniversity of Basel · CH
Funding
Agence Nationale de la Recherche ANR-14-CE12-0015-01Generalitat de Catalunya 2017SGR1323Horizon 2020 Framework Programme ERC-2016-CoG 725149Horizon 2020 Framework Programme H2020-MSCA-IF-2017Ministerio de Ciencia e Innovación CTQ2017-83745-PMinisterio de Ciencia e Innovación CTQ2017-87889-P
Abstract
Congenital hypogonadotropic hypogonadism (CHH) is a condition characterized by absent puberty and infertility due to gonadotropin releasing hormone (GnRH) deficiency, which is often associated with anosmia (Kallmann syndrome, KS). We identified loss-of-function heterozygous mutations in anti-Müllerian hormone (
Indexed as
Signal TransductionAdolescentAdultAmino Acid SequenceAnimalsAnti-Mullerian HormoneAxonsBone Morphogenetic Protein Receptors, Type ICell MovementChlorocebus aethiopsCOS CellsFemaleFertilityFetusGonadotropin-Releasing HormoneHeterozygoteAmhr2 protein, mouseAnti-Mullerian HormoneBone Morphogenetic Protein Receptors, Type IGonadotropin-Releasing HormoneLuteinizing HormoneReceptors, Transforming Growth Factor betaAMHcell migrationdevelopmental biologygeneticsgenomicsGnRHhumanKallmann's syndromemousereproduction
Identifiers
What OpenQuestion holds
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.