Evidence map›Paper›PMID 31291149›Full record

ArticleHypertension (Dallas, Tex. : 1979)2019

Characterization of Myocardial Microstructure and Function in an Experimental Model of Isolated Subendocardial Damage.

Niklas Beyhoff, David Lohr, Anna Foryst-Ludwig, Robert Klopfleisch, Sarah Brix, Jana Grune, Arne Thiele, Lasti Erfinanda, Arata Tabuchi, Wolfgang M Kuebler and 3 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Hypertension (Dallas, Tex. : 1979), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.7field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 34 citations in OpenAlex.

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  13. A Scoping Review of Galectin-3 as a Biomarker of Cardiovascular Diseases in Pediatric Populations.International journal of environmental research and public health · 2022
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  20. Evaluation of Galectin-3 Plasma Concentration in Adolescents with Ventricular Arrhythmia.International journal of environmental research and public health · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Niklas BeyhoffFrom the Charité-Universitätsmedizin Berlin, corporate member of Freie Universitaät Berlin, Humboldt-Universitaät zu Berlin, and Berlin Institute of Health, Institute of Pharmacology, Center for Cardiovascular Research, Berlin, Germany (N.B., A.F.-L., S.B., J.G., Arne Thiele, U.K.).
David LohrChair of Cellular and Molecular Imaging, Comprehensive Heart Failure Center (CHFC), University Hospital Wuerzburg, Germany (D.L., L.M.S.).
Anna Foryst-LudwigFrom the Charité-Universitätsmedizin Berlin, corporate member of Freie Universitaät Berlin, Humboldt-Universitaät zu Berlin, and Berlin Institute of Health, Institute of Pharmacology, Center for Cardiovascular Research, Berlin, Germany (N.B., A.F.-L., S.B., J.G., Arne Thiele, U.K.).
Robert KlopfleischDepartment of Veterinary Pathology, College of Veterinary Medicine, Freie Universität Berlin, Germany (R.K.).
Sarah BrixFrom the Charité-Universitätsmedizin Berlin, corporate member of Freie Universitaät Berlin, Humboldt-Universitaät zu Berlin, and Berlin Institute of Health, Institute of Pharmacology, Center for Cardiovascular Research, Berlin, Germany (N.B., A.F.-L., S.B., J.G., Arne Thiele, U.K.).
Jana GruneFrom the Charité-Universitätsmedizin Berlin, corporate member of Freie Universitaät Berlin, Humboldt-Universitaät zu Berlin, and Berlin Institute of Health, Institute of Pharmacology, Center for Cardiovascular Research, Berlin, Germany (N.B., A.F.-L., S.B., J.G., Arne Thiele, U.K.).
Arne ThieleFrom the Charité-Universitätsmedizin Berlin, corporate member of Freie Universitaät Berlin, Humboldt-Universitaät zu Berlin, and Berlin Institute of Health, Institute of Pharmacology, Center for Cardiovascular Research, Berlin, Germany (N.B., A.F.-L., S.B., J.G., Arne Thiele, U.K.).
Lasti ErfinandaDZHK (German Centre for Cardiovascular Research), Partner site Berlin, Germany (N.B., A.F.-L., S.B., J.G., Arne Thiele, L.E., Arata Tabuchi, W.M.K., B.P., U.K.).
Arata TabuchiDZHK (German Centre for Cardiovascular Research), Partner site Berlin, Germany (N.B., A.F.-L., S.B., J.G., Arne Thiele, L.E., Arata Tabuchi, W.M.K., B.P., U.K.).
Wolfgang M KueblerDZHK (German Centre for Cardiovascular Research), Partner site Berlin, Germany (N.B., A.F.-L., S.B., J.G., Arne Thiele, L.E., Arata Tabuchi, W.M.K., B.P., U.K.).
Burkert PieskeDZHK (German Centre for Cardiovascular Research), Partner site Berlin, Germany (N.B., A.F.-L., S.B., J.G., Arne Thiele, L.E., Arata Tabuchi, W.M.K., B.P., U.K.).
Laura M SchreiberChair of Cellular and Molecular Imaging, Comprehensive Heart Failure Center (CHFC), University Hospital Wuerzburg, Germany (D.L., L.M.S.).
Ulrich KintscherFrom the Charité-Universitätsmedizin Berlin, corporate member of Freie Universitaät Berlin, Humboldt-Universitaät zu Berlin, and Berlin Institute of Health, Institute of Pharmacology, Center for Cardiovascular Research, Berlin, Germany (N.B., A.F.-L., S.B., J.G., Arne Thiele, U.K.).
Charité - Universitätsmedizin Berlin · DEGerman Centre for Cardiovascular Research · DEFreie Universität Berlin · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Subendocardial damage is among the first cardiac manifestations of hypertension and is already present in asymptomatic disease states. Accordingly, markers of subendocardial impairment may facilitate early detection of cardiac damages and risk stratification under these conditions. This study aimed to investigate the impact of subendocardial damage on myocardial microstructure and function to elucidate early pathophysiologic processes and to identify corresponding diagnostic measures. Mice (n=38) were injected with isoproterenol to induce isolated subendocardial scarring or saline as corresponding control. Cardiac function and myocardial deformation were determined by high-frequency echocardiography. The cardiac stress response was assessed in a graded exercise test and during dobutamine stress echocardiography. Myocardial microstructure was studied ex vivo by 7 T diffusion tensor magnetic resonance imaging at a spatial resolution of 100×100×100 µm

Indexed as

Image Interpretation, Computer-AssistedAnimalsBiopsy, NeedleDisease Models, AnimalEchocardiographyEndocardiumFibrosisGermanyHumansImmunohistochemistryInjections, SubcutaneousIsoproterenolLinear ModelsMagnetic Resonance Imaging, CineMiceMice, Inbred StrainsIsoproterenoldiffusion tensor magnetic resonance imagingmyocardial strain; remodelingspeckle trackingsubendocardium

Identifiers

PMID31291149
PMCPMC6635061
OpenAlexW2959987325

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.