Evidence map›Paper›PMID 31291142›Full record

ArticleAmerican journal of physiology. Cell physiology2019

p38-Regulated/activated protein kinase plays a pivotal role in protecting heart against ischemia-reperfusion injury and preserving cardiac performance.

Yu Tina Zhao, Jianfeng Du, Naohiro Yano, Hao Wang, Jianguo Wang, Patrycja M Dubielecka, Ling X Zhang, Gangjian Qin, Shougang Zhuang, Paul Y Liu and 2 more

Open access · bronzeAbstract read
In one paragraph

Article in American journal of physiology. Cell physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 2 countries.

Yu Tina ZhaoDepartment of Surgery, Roger Williams Medical Center, Boston University School of Medicine, Providence, Rhode Island.
Jianfeng DuDepartment of Surgery, Roger Williams Medical Center, Boston University School of Medicine, Providence, Rhode Island.
Naohiro YanoDepartment of Surgery, Roger Williams Medical Center, Boston University School of Medicine, Providence, Rhode Island.
Hao WangDepartment of Surgery, Roger Williams Medical Center, Boston University School of Medicine, Providence, Rhode Island.
Jianguo WangDepartment of Surgery, Roger Williams Medical Center, Boston University School of Medicine, Providence, Rhode Island.
Patrycja M DubieleckaDepartment of Medicine, Rhode Island Hospital, Brown University, Providence, Rhode Island.
Ling X ZhangDepartment of Medicine, Rhode Island Hospital, Brown University, Providence, Rhode Island.
Gangjian QinDepartment of Biomedical Engineering, University of Alabama at Birmingham, Birmingham, Alabama.
Shougang ZhuangDepartment of Medicine, Rhode Island Hospital, Brown University, Providence, Rhode Island.
Paul Y LiuDepartment of Plastic Surgery, Rhode Island Hospital, Brown University, Providence, Rhode Island.
Y Eugene ChinInstitute of Health Sciences, Chinese Academy of Sciences-Jiaotong University School of Medicine, Shanghai, China.
Ting C ZhaoDepartment of Surgery, Roger Williams Medical Center, Boston University School of Medicine, Providence, Rhode Island.
Roger Williams Medical Center · USBrown University · USRhode Island Hospital · USBoston University · USChinese Academy of Sciences · CNProvidence College · USUniversity of Alabama at Birmingham · US

Funding

Histone Deacetylase Inhibition: A Novel Approach to CardioprotectionR01HL089405 · NHLBI · ROGER WILLIAMS MEDICAL CENTER · PI ZHAO, TING C · 2009 to 2020
$3.4M
p38 acetylation: Novel signaling mechanisms and myocardial protectionR01HL115265 · NHLBI · ROGER WILLIAMS MEDICAL CENTER · PI ZHAO, TING C · 2013 to 2016
$1.6M
NHLBI NIH HHS R01 HL089405NHLBI NIH HHS R01 HL115265
6 · The paper itself

Abstract

p38-Regulated/activated protein kinase (PRAK) plays a critical role in modulating cellular survival and biological function. However, the function of PRAK in the regulation of myocardial ischemic injury remains unknown. This study is aimed at determining the function of PRAK in modulating myocardial ischemia-reperfusion injury and myocardial remodeling following myocardial infarction. Hearts were isolated from adult male homozygous PRAK

Indexed as

AnimalsIntracellular Signaling Peptides and ProteinsIsolated Heart PreparationMaleMiceMice, Inbred C57BLMice, KnockoutMyocardial ContractionMyocardial Reperfusion Injuryp38 Mitogen-Activated Protein KinasesProtein Serine-Threonine KinasesIntracellular Signaling Peptides and ProteinsMAP-kinase-activated kinase 5p38 Mitogen-Activated Protein KinasesProtein Serine-Threonine Kinasesfunction recoveryheartischemia-reperfusionmyocardial remodelingPRAK

Identifiers

PMID31291142
PMCPMC6766622
OpenAlexW2962311481

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.