Evidence map›Paper›PMID 31291141›Full record

ArticleAmerican journal of physiology. Cell physiology2019

Autonomic modulation of the electrical substrate in mice haploinsufficient for cardiac sodium channels: a model of the Brugada syndrome.

Malcolm Finlay, Justine Bhar-Amato, Keat-Eng Ng, Diogo Santos, Michele Orini, Vishal Vyas, Peter Taggart, Andrew A Grace, Christopher L-H Huang, Pier D Lambiase and 1 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Cell physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. NovelFrontiers in cardiovascular medicine · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Malcolm FinlayWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.
Justine Bhar-AmatoInstitute of Cardiovascular Science, University College London, London, United Kingdom.
Keat-Eng NgWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.
Diogo SantosInstitute of Cardiovascular Science, University College London, London, United Kingdom.
Michele OriniInstitute of Cardiovascular Science, University College London, London, United Kingdom.
Vishal VyasWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.
Peter TaggartInstitute of Cardiovascular Science, University College London, London, United Kingdom.
Andrew A GraceDepartment of Biochemistry, University of Cambridge, Cambridge, United Kingdom.
Christopher L-H HuangDepartment of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, United Kingdom.ORCID 0000-0001-9553-6112
Pier D LambiaseInstitute of Cardiovascular Science, University College London, London, United Kingdom.
Andrew TinkerWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.
University College London · GBQueen Mary University of London · GBUniversity of Cambridge · GB

Funding

British Heart Foundation RG/15/15/31742Medical Research Council
6 · The paper itself

Abstract

A murine line haploinsufficient in the cardiac sodium channel has been used to model human Brugada syndrome: a disease causing sudden cardiac death due to lethal ventricular arrhythmias. We explored the effects of cholinergic tone on electrophysiological parameters in wild-type and genetically modified, heterozygous,

Indexed as

Isolated Heart PreparationAnimalsBrugada SyndromeFemaleHaploinsufficiencyMaleMiceMice, KnockoutMyocardial ContractionNAV1.5 Voltage-Gated Sodium ChannelSodium ChannelsNAV1.5 Voltage-Gated Sodium ChannelScn5a protein, mouseSodium Channelsautonomic nervous systemBrugada syndromeconductionhaploinsufficiency

Identifiers

PMID31291141
PMCPMC6766618
OpenAlexW2958802106

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.