ArticleMolecular nutrition & food research2019
Plasma Metabolites Associated with Frequent Red Wine Consumption: A Metabolomics Approach within the PREDIMED Study.
Article in Molecular nutrition & food research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The trial behind it
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Who cites it
13 citing papers in PubMed.
- Plasma metabolite profiles associated with the World Cancer Research Fund/American Institute for Cancer Research lifestyle score and future risk of cardiovascular disease and type 2 diabetes.Cardiovascular diabetology · 2023Trial
- Urine Metabolites Associated with the Dietary Approaches to Stop Hypertension (DASH) Diet: Results from the DASH-Sodium Trial.Molecular nutrition & food research · 2021Trial
- Trial
- Plasma metabolite profile of legume consumption and future risk of type 2 diabetes and cardiovascular disease.Cardiovascular diabetology · 2024Article
- Olive oil consumption, plasma metabolites, and risk of type 2 diabetes and cardiovascular disease.Cardiovascular diabetology · 2023Article
- Exploring Human Metabolome after Wine Intake-A Review.Molecules (Basel, Switzerland) · 2023Review
- Plasma Metabolite Profiles Associated with the Amount and Source of Meat and Fish Consumption and the Risk of Type 2 Diabetes.Molecular nutrition & food research · 2022Article
- Article
- Dairy consumption, plasma metabolites, and risk of type 2 diabetes.The American journal of clinical nutrition · 2021Article
- Circulating amino acids and amino acid-related metabolites and risk of breast cancer among predominantly premenopausal women.NPJ breast cancer · 2021Article
- Serum Metabolites Associated with Healthy Diets in African Americans and European Americans.The Journal of nutrition · 2021Article
- Promoting Human Nutrition and Health through Plant Metabolomics: Current Status and Challenges.Biology · 2020Review
- Plasma Metabolomics Profiles are Associated with the Amount and Source of Protein Intake: A Metabolomics Approach within the PREDIMED Study.Molecular nutrition & food research · 2020Article
Corrections and comments
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Authors and funding
23 authors.
Funding
Abstract
scopeThe relationship between red wine (RW) consumption and metabolism is poorly understood. It is aimed to assess the systemic metabolomic profiles in relation to frequent RW consumption as well as the ability of a set of metabolites to discriminate RW consumers. METHODS AND
resultsA cross-sectional analysis of 1157 participants is carried out. Subjects are divided as non-RW consumers versus RW consumers (>1 glass per day RW [100 mL per day]). Plasma metabolomics analysis is performed using LC-MS. Associations between 386 identified metabolites and RW consumption are assessed using elastic net regression analysis taking into consideration baseline significant covariates. Ten-cross-validation (CV) is performed and receiver operating characteristic curves are constructed in each of the validation datasets based on weighted models. A subset of 13 metabolites is consistently selected and RW consumers versus nonconsumers are discriminated. Based on the multi-metabolite model weighted with the regression coefficients of metabolites, the area under the curve is 0.83 (95% CI: 0.80-0.86). These metabolites mainly consisted of lipid species, some organic acids, and alkaloids.
conclusionsA multi-metabolite model identified in a Mediterranean population appears useful to discriminate between frequent RW consumers and nonconsumers. Further studies are needed to assess the contribution of these metabolites in health and disease.
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