Evidence map›Paper›PMID 31291028›Full record

ArticleChemistry (Weinheim an der Bergstrasse, Germany)2019

Ultra-High to Ultra-Low Drug-Loaded Micelles: Probing Host-Guest Interactions by Fluorescence Spectroscopy.

Michael M Lübtow, Henning Marciniak, Alexander Schmiedel, Markus Roos, Christoph Lambert, Robert Luxenhofer

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Biological ActivityBiomacromolecules · 2023
    Article
  5. Review
  6. Article
  7. Review
  8. Review
  9. Review
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Michael M LübtowFunctional Polymer Materials, Chair for Advanced Materials Synthesis, Department of Chemistry and Pharmacy and Bavarian Polymer Institute, University of Würzburg, Röntgenring 11, 97070, Würzburg, Germany.
Henning MarciniakInstitute of Organic Chemistry and Center for Nanosystems Chemistry, University of Würzburg, Am Hubland, 97070, Würzburg, Germany.
Alexander SchmiedelInstitute of Organic Chemistry and Center for Nanosystems Chemistry, University of Würzburg, Am Hubland, 97070, Würzburg, Germany.
Markus RoosInstitute of Organic Chemistry and Center for Nanosystems Chemistry, University of Würzburg, Am Hubland, 97070, Würzburg, Germany.
Christoph LambertInstitute of Organic Chemistry and Center for Nanosystems Chemistry, University of Würzburg, Am Hubland, 97070, Würzburg, Germany.ORCID http://orcid.org/0000-0002-9652-9165
Robert LuxenhoferFunctional Polymer Materials, Chair for Advanced Materials Synthesis, Department of Chemistry and Pharmacy and Bavarian Polymer Institute, University of Würzburg, Röntgenring 11, 97070, Würzburg, Germany.ORCID http://orcid.org/0000-0001-5567-7404

Funding

Bayerisches Staatsministerium für Wissenschaft, Forschung und Kunst SolTech ConsortiumDeutsche Forschungsgemeinschaft 398461692Evonik Stiftung n.a.
6 · The paper itself

Abstract

Polymer micelles are an attractive means to solubilize water insoluble compounds such as drugs. Drug loading, formulations stability and control over drug release are crucial factors for drug-loaded polymer micelles. The interactions between the polymeric host and the guest molecules are considered critical to control these factors but typically barely understood. Here, we compare two isomeric polymer micelles, one of which enables ultra-high curcumin loading exceeding 50 wt.%, while the other allows a drug loading of only 25 wt.%. In the low capacity micelles, steady-state fluorescence revealed a very unusual feature of curcumin fluorescence, a high energy emission at 510 nm. Time-resolved fluorescence upconversion showed that the fluorescence life time of the corresponding species is too short in the high-capacity micelles, preventing an observable emission in steady-state. Therefore, contrary to common perception, stronger interactions between host and guest can be detrimental to the drug loading in polymer micelles.

Indexed as

MicellesAntineoplastic AgentsColoring AgentsCurcuminDrug CarriersDrug LiberationHydrogen-Ion ConcentrationHydrophobic and Hydrophilic InteractionsKineticsLightParticle SizePolymersSolubilitySpectrometry, FluorescenceTemperatureAntineoplastic AgentsColoring AgentsCurcuminDrug CarriersMicellesPolymerscurcumindrug deliveryfluorescencepoly(2-oxazine)poly(2-oxazoline)polymer-drug interactionupconversion

Identifiers

PMID31291028
PMCPMC6790594

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.