Evidence map›Paper›PMID 31290674›Full record

ArticleOrganic letters2019

Palladium-Catalyzed Suzuki-Miyaura Reactions of Aspartic Acid Derived Phenyl Esters.

Amira H Dardir, Nilay Hazari, Scott J Miller, Christopher R Shugrue

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Organic letters, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Organometallic AlaChem catalysis · 2021
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Amira H DardirThe Department of Chemistry , Yale University , P.O. Box 208107, New Haven , Connecticut 06520 , United States.
Nilay HazariThe Department of Chemistry , Yale University , P.O. Box 208107, New Haven , Connecticut 06520 , United States.ORCID 0000-0001-8337-198X
Scott J MillerThe Department of Chemistry , Yale University , P.O. Box 208107, New Haven , Connecticut 06520 , United States.ORCID 0000-0001-7817-1318
Christopher R ShugrueThe Department of Chemistry , Yale University , P.O. Box 208107, New Haven , Connecticut 06520 , United States.ORCID 0000-0002-3504-9475

Funding

Site-Selective Catalysis for Bioactive Scaffold DiversificationR35GM132092 · NIGMS · YALE UNIVERSITY · PI Scott J Miller · 2019 to 2026
$6.3M
Mechanistic Studies to Rationally Design Ni and Pd Catalysts for Cross-CouplingR01GM120162 · NIGMS · YALE UNIVERSITY · PI HAZARI, NILAY · 2016 to 2020
$1.6M
NIGMS NIH HHS R01 GM120162NIGMS NIH HHS R35 GM132092
6 · The paper itself

Abstract

Transition-metal-catalyzed transformations of amino acids and peptides could provide a powerful method for their site-selective modification. Here, we report non-decarbonylative Pd-catalyzed Suzuki-Miyaura reactions of phenyl ester derivatives of aspartic acid to form aryl-amino ketones. These products are potentially important in the synthesis of pharmaceuticals, and our methodology represents a new route to access molecules of this type.

Indexed as

Aspartic AcidCatalysisEstersKetonesPalladiumAspartic AcidEstersKetonesPalladium

Identifiers

PMID31290674
PMCPMC6939165

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.