ArticleLab on a chip2019
Clinical translation of microfluidic sensor devices: focus on calibration and analytical robustness.
Article in Lab on a chip, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed.
- Noninvasive measurement of glucose and lactate in thermoregulatory sweat in neonates and adults.Science advances · 2026Article
- A Universal Optical Microanalysis Platform Based on Micropipette Tips.Sensors and actuators. B, Chemical · 2026Article
- Nanozyme-Driven Signal Amplification in Cancer Biosensing: Innovations Toward Precision and Point-of-Care Oncology.Micromachines · 2026Review
- Rapid culture-free diagnosis of clinical pathogens via integrated microfluidic-Raman micro-spectroscopy.Nature communications · 2025Article
- Label-free phenotypic antimicrobial susceptibility testing on microfluidic platforms: a review of advances and translation.Mikrochimica acta · 2025Review
- The Neurochemical Signature of Cardiac Arrest: A Multianalyte Online Microdialysis Study.ACS chemical neuroscience · 2025Article
- Versatile, in-line optical oxygen tension sensors for continuous monitoring duringSensors & diagnostics · 2024Article
- Computational Modeling as a Tool to Drive the Development of a Novel, Chemical Device for Monitoring the Injured Brain and Body.ACS chemical neuroscience · 2023Article
- Monitoring Neurochemistry in Traumatic Brain Injury Patients Using Microdialysis Integrated with Biosensors: A Review.Metabolites · 2022Review
- Real-Time Monitoring of Biomolecules: Dynamic Response Limits of Affinity-Based Sensors.ACS sensors · 2022Article
- Cerebral Microdialysate Metabolite Monitoring using Mid-infrared Spectroscopy.Analytical chemistry · 2021Article
- Fiber-Based Electrochemical Biosensors for Monitoring pH and Transient Neurometabolic Lactate.Analytical chemistry · 2021Article
- Emerging Lab-on-a-Chip Approaches for Liquid Biopsy in Lung Cancer: Status in CTCs and ctDNA Research and Clinical Validation.Cancers · 2021Review
- Traumatic brain injury neuroelectrochemical monitoring: behind-the-ear micro-instrument and cloud application.Journal of neuroengineering and rehabilitation · 2020Article
- Dexamethasone-Enhanced Microdialysis and Penetration Injury.Frontiers in bioengineering and biotechnology · 2020Review
- Portable Microfluidic Biosensing System for Real-Time Analysis of Microdialysate in Transplant Kidneys.Analytical chemistry · 2019Article
- 3D printed microfluidic device for online detection of neurochemical changes with high temporal resolution in human brain microdialysate.Lab on a chip · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
We present approaches to facilitate the use of microfluidics outside of the laboratory, in our case within a clinical setting and monitoring from human subjects, where the complexity of microfluidic devices requires high skill and expertise and would otherwise limit translation. Microfluidic devices show great potential for converting complex laboratory protocols into on-chip processes. We demonstrate a flexible microfluidic platform can be coupled to microfluidic biosensors and used in conjunction with clinical microdialysis. The versatility is demonstrated through a series of examples of increasing complexity including analytical processes relevant to a clinical environment such as automatic calibration, standard addition, and more general processes including system optimisation, reagent addition and homogenous enzyme reactions. The precision and control offered by this set-up enables the use of microfluidics by non-experts in clinical settings, increasing uptake and usage in real-world scenarios. We demonstrate how this type of system is helpful in guiding physicians in real-time clinical decision-making.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.