Evidence map›Paper›PMID 31290487›Full record

ArticleChemical communications (Cambridge, England)2019

A new strategy for the in vitro selection of stapled peptide inhibitors by mRNA display.

Emil S Iqbal, Stacie L Richardson, Nicolas A Abrigo, Kara K Dods, H Estheban Osorio Franco, Heather S Gerrish, Hari Kiran Kotapati, Iain M Morgan, Douglas S Masterson, Matthew C T Hartman

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical communications (Cambridge, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Review
  2. Article
  3. Using display technologies to identify macrocyclic peptide antibiotics.Biochimica et biophysica acta. Molecular cell research · 2023
    Review
  4. Article
  5. Article
  6. Article
  7. Non-canonical Amino Acid Substrates of E. coli Aminoacyl-tRNA Synthetases.Chembiochem : a European journal of chemical biology · 2022
    Review
  8. Review
  9. Review
  10. Article
  11. Review
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Emil S IqbalDepartment of Chemistry, Virginia Commonwealth University, 1001 West Main Street, P. O. Box 842006, Richmond, VA 23284, USA. mchartman@vcu.edu and Massey Cancer Center, Virginia Commonwealth University, 401 College Street, Richmond, VA 23298, USA.ORCID http://orcid.org/0000-0002-5825-1203
Stacie L RichardsonDepartment of Chemistry, Virginia Commonwealth University, 1001 West Main Street, P. O. Box 842006, Richmond, VA 23284, USA. mchartman@vcu.edu and Massey Cancer Center, Virginia Commonwealth University, 401 College Street, Richmond, VA 23298, USA.
Nicolas A AbrigoDepartment of Chemistry, Virginia Commonwealth University, 1001 West Main Street, P. O. Box 842006, Richmond, VA 23284, USA. mchartman@vcu.edu and Massey Cancer Center, Virginia Commonwealth University, 401 College Street, Richmond, VA 23298, USA.
Kara K DodsDepartment of Chemistry, Virginia Commonwealth University, 1001 West Main Street, P. O. Box 842006, Richmond, VA 23284, USA. mchartman@vcu.edu and Massey Cancer Center, Virginia Commonwealth University, 401 College Street, Richmond, VA 23298, USA.ORCID http://orcid.org/0000-0002-5603-6948
H Estheban Osorio FrancoDepartment of Chemistry, Virginia Commonwealth University, 1001 West Main Street, P. O. Box 842006, Richmond, VA 23284, USA. mchartman@vcu.edu and Massey Cancer Center, Virginia Commonwealth University, 401 College Street, Richmond, VA 23298, USA.
Heather S GerrishDepartment of Chemistry, Virginia Commonwealth University, 1001 West Main Street, P. O. Box 842006, Richmond, VA 23284, USA. mchartman@vcu.edu and Massey Cancer Center, Virginia Commonwealth University, 401 College Street, Richmond, VA 23298, USA.
Hari Kiran KotapatiSchool of Mathematics & Natural Sciences, Chemistry & Biochemistry, 118 College Drive #5043, Hattiesburg, MS 39406, USA.ORCID http://orcid.org/0000-0002-8157-9688
Iain M MorganMassey Cancer Center, Virginia Commonwealth University, 401 College Street, Richmond, VA 23298, USA and Philips Institute for Oral Health Research, Department of Oral and Craniofacial Molecular Biology, School of Dentistry, Virginia Commonwealth University, Box 980566, Richmond, VA 23298, USA.
Douglas S MastersonSchool of Mathematics & Natural Sciences, Chemistry & Biochemistry, 118 College Drive #5043, Hattiesburg, MS 39406, USA.
Matthew C T HartmanDepartment of Chemistry, Virginia Commonwealth University, 1001 West Main Street, P. O. Box 842006, Richmond, VA 23284, USA. mchartman@vcu.edu and Massey Cancer Center, Virginia Commonwealth University, 401 College Street, Richmond, VA 23298, USA.ORCID http://orcid.org/0000-0003-0210-1422

Funding

Virus Vector Shared ResourceP30CA016059 · NCI · VIRGINIA COMMONWEALTH UNIVERSITY · PI Keri R Maher · 1985 to 2026
$51.0M
Research Supplement to Promote Diversity in Health Related ResearchUL1TR002649 · NCATS · VIRGINIA COMMONWEALTH UNIVERSITY · PI MOELLER, FREDERICK GERARD · 2018 to 2022
$19.1M
XLF in double-strand break repair and chemo/radiosensitizationR01CA166264 · NCI · VIRGINIA COMMONWEALTH UNIVERSITY · PI HARTMAN, MATTHEW C · 2013 to 2017
$1.5M
NCATS NIH HHS UL1 TR002649NCI NIH HHS P30 CA016059NCI NIH HHS R01 CA166264
6 · The paper itself

Abstract

Hydrocarbon stapled peptides are promising therapeutics for inhibition of intracellular protein-protein interactions. Here we develop a new high-throughput strategy for hydrocarbon stapled peptide discovery based on mRNA display of peptides containing α-methyl cysteine and cyclized with m-dibromoxylene. We focus on development of a peptide binder to the HPV16 E2 protein.

Indexed as

AlkylationAmino Acid SequenceBromodomain Containing ProteinsCell Cycle ProteinsCyclizationCysteineDirected Molecular EvolutionDNA-Binding ProteinsHydrocarbons, BrominatedNuclear ProteinsOncogene Proteins, ViralPeptide LibraryPeptidesProtein BindingProtein EngineeringRNA, Messengeralpha,alpha'-dibromoxyleneBRD4 protein, humanBromodomain Containing ProteinsCell Cycle ProteinsCysteineDNA-Binding ProteinsE2 protein, Human papillomavirus type 16Hydrocarbons, BrominatedNuclear ProteinsOncogene Proteins, ViralPeptide LibraryPeptidesRNA, MessengerTranscription Factors

Identifiers

PMID31290487
PMCPMC7077329

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.