Evidence map›Paper›PMID 31290383›Full record

ArticleCardiology in the young2019

Biomarkers improve prediction of 30-day unplanned readmission or mortality after paediatric congenital heart surgery.

Jeremiah R Brown, Meagan E Stabler, Devin M Parker, Luca Vricella, Sara Pasquali, JoAnna K Leyenaar, Andrew R Bohm, Todd MacKenzie, Chirag Parikh, Marshall L Jacobs and 2 more

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cardiology in the young, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07029230 (Biomarker in Congenital Cardiac Surgery - sST2 Marker in Heart Failure in Congenital Heart Disease After Surgery Research and Translational Study), which is not on this map. Cited by 8 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 2 pooled it
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07029230 recruitingnot on this mapstarted 2025, after this paper: background citation

Biomarker in Congenital Cardiac Surgery - sST2 Marker in Heart Failure in Congenital Heart Disease After Surgery Research and Translational Study

TypeobservationalSponsorMartin SchweigerRan2025 to 2029Enrolled225ConditionsCongenital Heart Surgery, Congenital Heart Disease in Children, Fontan Physiology
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 2 syntheses or guidelines pooled it, 10 citations in OpenAlex.

  1. Pooled it
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  3. Review
  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 1 country.

Jeremiah R BrownDepartment of Epidemiology, Geisel School of Medicine, Lebanon, NH, USA.
Meagan E StablerDepartment of Epidemiology, Geisel School of Medicine, Lebanon, NH, USA.
Devin M ParkerDepartment of Epidemiology, Geisel School of Medicine, Lebanon, NH, USA.
Luca VricellaDivision of Cardiac Surgery, Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Sara PasqualiDivision of Pediatric Cardiology, Department of Pediatrics, C.S. Mott Children's Hospital, University of Michigan, Ann Arbor, MI, USA.
JoAnna K LeyenaarThe Dartmouth Institute for Health Policy and Clinical Practice, Geisel School of Medicine, Hanover, NH, USA.
Andrew R BohmDepartment of Epidemiology, Geisel School of Medicine, Lebanon, NH, USA.
Todd MacKenzieDepartment of Epidemiology, Geisel School of Medicine, Lebanon, NH, USA.
Chirag ParikhDivision of Nephrology, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Marshall L JacobsDivision of Cardiovascular Surgery, Department of Surgery, Johns Hopkins All Children's Heart Institute, Johns Hopkins All Children's Hospital and Florida Hospital for Children, Saint Petersburg, Tampa, and Orlando, FL, USA.
Jeffrey P JacobsDivision of Cardiovascular Surgery, Department of Surgery, Johns Hopkins All Children's Heart Institute, Johns Hopkins All Children's Hospital and Florida Hospital for Children, Saint Petersburg, Tampa, and Orlando, FL, USA.
Allen D EverettDivision of Pediatric Cardiology, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Johns Hopkins Medicine · USC. S. Mott Children's Hospital · USDartmouth College · USDartmouth–Hitchcock Medical Center · USDartmouth Institute for Health Policy and Clinical Practice · USJohns Hopkins All Children's Hospital · USJohns Hopkins University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Novel Biomarkers to Predict Readmission in Pediatric and Adult Heart SurgeryR01HL119664 · NHLBI · DARTMOUTH COLLEGE · PI BROWN, JEREMIAH R · 2014 to 2017
$3.2M
NCATS NIH HHS UL1 TR001863NHLBI NIH HHS R01 HL119664
6 · The paper itself

Abstract

objectiveTo evaluate the association between novel pre- and post-operative biomarker levels and 30-day unplanned readmission or mortality after paediatric congenital heart surgery.

methodsChildren aged 18 years or younger undergoing congenital heart surgery (n = 162) at Johns Hopkins Hospital from 2010 to 2014 were enrolled in the prospective cohort. Collected novel pre- and post-operative biomarkers include soluble suppression of tumorgenicity 2, galectin-3, N-terminal prohormone of brain natriuretic peptide, and glial fibrillary acidic protein. A model based on clinical variables from the Society of Thoracic Surgery database was developed and evaluated against two augmented models.

resultsUnplanned readmission or mortality within 30 days of cardiac surgery occurred among 21 (13%) children. The clinical model augmented with pre-operative biomarkers demonstrated a statistically significant improvement over the clinical model alone with a receiver-operating characteristics curve of 0.754 (95% confidence interval: 0.65-0.86) compared to 0.617 (95% confidence interval: 0.47-0.76; p-value: 0.012). The clinical model augmented with pre- and post-operative biomarkers demonstrated a significant improvement over the clinical model alone, with a receiver-operating characteristics curve of 0.802 (95% confidence interval: 0.72-0.89; p-value: 0.003).

conclusionsNovel biomarkers add significant predictive value when assessing the likelihood of unplanned readmission or mortality after paediatric congenital heart surgery. Further exploration of the utility of these novel biomarkers during the pre- or post-operative period to identify early risk of mortality or readmission will aid in determining the clinical utility and application of these biomarkers into routine risk assessment.

Indexed as

AdolescentBiomarkersCardiac Surgical ProceduresChildChild, PreschoolDatabases, FactualFemaleGalectin 3Heart Defects, CongenitalHumansInfantInfant, NewbornLogistic ModelsMaleMarylandNatriuretic Peptide, BrainBiomarkersGalectin 3Natriuretic Peptide, BrainPeptide FragmentsbiomarkersPaediatric CHDpredictionreadmission

Identifiers

PMID31290383
PMCPMC6711799
OpenAlexW2961957743

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.