Evidence map›Paper›PMID 31290366›Full record

ReviewNanomedicine (London, England)2019

Silk fibroin-based nanotherapeutics: application in the treatment of colonic diseases.

Shuangquan Gou, Yamei Huang, Junsik Sung, Bo Xiao, Didier Merlin

Abstract readReview
In one paragraph

Review in Nanomedicine (London, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Shuangquan GouState Key Laboratory of Silkworm Genome Biology, School of Materials & Energy, Southwest University, Beibei, Chongqing 400715, PR China.
Yamei HuangState Key Laboratory of Silkworm Genome Biology, School of Materials & Energy, Southwest University, Beibei, Chongqing 400715, PR China.
Junsik SungInstitute for Biomedical Sciences, Center for Diagnostics & Therapeutics, Georgia State University, Atlanta, GA 30302, USA.
Bo XiaoState Key Laboratory of Silkworm Genome Biology, School of Materials & Energy, Southwest University, Beibei, Chongqing 400715, PR China.
Didier MerlinInstitute for Biomedical Sciences, Center for Diagnostics & Therapeutics, Georgia State University, Atlanta, GA 30302, USA.

Funding

Novel Therapeutic Approaches For Treatment of Intestinal InflammationR01DK107739 · NIDDK · GEORGIA STATE UNIVERSITY · PI DENNING, TIMOTHY L, MERLIN, DIDIER · 2017 to 2020
$1.4M
Small intestinal PepT1 expression plays a critical role in maintaining intestinal homeostasis and in shaping the gut microbiotaI01BX002526 · VA · VETERANS HEALTH ADMINISTRATION · PI MERLIN, DIDIER · 2014 to 2024
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BLR&D Research Career Scientist Award ApplicationIK6BX004476 · VA · VETERANS HEALTH ADMINISTRATION · PI MERLIN, DIDIER · 2019 to 2025
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BLRD VA I01 BX002526BLRD VA IK6 BX004476NIDDK NIH HHS R01 DK107739
6 · The paper itself

Abstract

The incidence of colonic diseases (e.g., inflammatory bowel diseases and colon cancer) is rapidly rising. Nanotherapeutic has been considered as a promising strategy in the treatment of colonic diseases. Silk fibroin (SF) has been widely used as a drug-carrier matrix. Interestingly, SF-based nanoparticles (SFNPs) have intrinsic anti-inflammatory activity, wound healing capacity and lysosomal environment-responsive drug-release property. With further investigations, the sequences of SF molecules could be precisely modified through chemical reactions or transgenic techniques to greatly improve the properties of SFNPs. Here, we review recent advances in the application of SFNPs toward the treatment of colonic diseases. We also discuss future developments that might improve the anti-inflammatory and anti-colon cancer activities of SF-based nanotherapeutics.

Indexed as

AnimalsColonic NeoplasmsFibroinsHumansInflammatory Bowel DiseasesNanomedicineNanoparticlesFibroinscolon cancerinflammatory bowel diseasenanoparticlesilk fibrointreatment

Identifiers

PMID31290366
PMCPMC7026768

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.