Evidence map›Paper›PMID 31290330›Full record

ArticleMolecular pharmaceutics2019

An [

Hua Guo, Harikrishna Kommidi, Uday B Maachani, Julia C Voronina, Weiqi Zhang, Rajiv S Magge, Jana Ivanidze, Amy P Wu, Mark M Souweidane, Omer Aras and 1 more

Open access · greenAbstract read
In one paragraph

Article in Molecular pharmaceutics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. A proof-of-concept study on the use of a fluorescein-basedEJNMMI radiopharmacy and chemistry · 2022
    Article
  2. Neuroinflammation-Driven Lymphangiogenesis in CNS Diseases.Frontiers in cellular neuroscience · 2021
    Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Hua Guo
Harikrishna Kommidi
Uday B Maachani
Julia C Voronina
Weiqi Zhang
Rajiv S Magge
Jana Ivanidze
Amy P WuDepartment of Otolaryngology - Head & Neck Surgery, Northwell Health , Hofstra Northwell School of Medicine , New York , New York 10075 , United States.
Mark M Souweidane
Omer ArasDepartment of Radiology , Memorial Sloan Kettering Cancer Center , New York , New York 10065 , United States.ORCID 0000-0003-1758-0542
Cornell University · USMemorial Sloan Kettering Cancer Center · USNorthwell Health · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
New PET /near IR-fluorescence tools for multimodal imaging in oncologyR00EB013904 · NIBIB · WEILL MEDICAL COLL OF CORNELL UNIV · PI TING, RICHARD · 2014 to 2016
$724k
New PET /near IR-fluorescence tools for multimodal imaging in oncologyK99EB013904 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI TING, RICHARD · 2012 to 2013
$180k
NCI NIH HHS P30 CA008748NIBIB NIH HHS K99 EB013904NIBIB NIH HHS R00 EB013904
6 · The paper itself

Abstract

The small molecule fluorescein is commonly used to guide the repair of cerebral spinal fluid leaks (CSFLs) in the clinic. We modified fluorescein so that it is also visible by positron emission tomography (PET). This probe was used to quantitatively track the fast distribution of small molecules in the CSF of rats. We tested this probe in models relevant to the clinical diagnosis and treatment of central nervous system (CNS) diseases that affect CSF flow. In this study, fluorescein was radiolabeled with fluorine-18 to produce Fc-AMBF

Indexed as

Fluorine RadioisotopesAnimalsCell Line, TumorCentral Nervous System DiseasesCerebrospinal FluidCerebrospinal Fluid LeakCerebrospinal Fluid ShuntsDisease Models, AnimalFluoresceinFluorescent DyesHumansInjections, SpinalMalePositron-Emission TomographyRadiopharmaceuticalsRatsFluoresceinFluorescent DyesFluorine-18Fluorine RadioisotopesRadiopharmaceuticalscerebrospinal fluid leakfluorescencelumboperitoneal shuntingPETsmall molecule clearance

Identifiers

PMID31290330
PMCPMC7478905
OpenAlexW2960344769

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.