Evidence map›Paper›PMID 31290283›Full record

ArticleCancer medicine2019

Prognostic impact of extratumoral perineural invasion in patients with oral cavity squamous cell carcinoma.

Li-Yu Lee, Dante De Paz, Chien-Yu Lin, Kang-Hsing Fan, Hung-Ming Wang, Chia-Hsun Hsieh, Li-Ang Lee, Tzu-Chen Yen, Chun-Ta Liao, Ching-Hua Yeh and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Li-Yu LeeDepartment of Pathology, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan, R.O.C.
Dante De PazDepartment of Plastic and Reconstructive Surgery, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan, R.O.C.
Chien-Yu LinDepartment of Head and Neck Oncology Group, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan, R.O.C.
Kang-Hsing FanDepartment of Head and Neck Oncology Group, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan, R.O.C.
Hung-Ming WangDepartment of Head and Neck Oncology Group, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan, R.O.C.
Chia-Hsun HsiehDepartment of Head and Neck Oncology Group, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan, R.O.C.
Li-Ang LeeDepartment of Head and Neck Oncology Group, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan, R.O.C.ORCID 0000-0001-8414-595X
Tzu-Chen YenDepartment of Head and Neck Oncology Group, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan, R.O.C.
Chun-Ta LiaoDepartment of Head and Neck Oncology Group, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan, R.O.C.
Ching-Hua YehMedicinal Botanicals and Health Applications, Da Yeh University, Changhua, Taiwan, R.O.C.
Chung-Jan KangDepartment of Head and Neck Oncology Group, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan, R.O.C.ORCID 0000-0002-5333-9396
Chang Gung Memorial Hospital · TWChang Gung University · TWDayeh University · TWLinkou Chang Gung Memorial Hospital · TW

Funding

Chang Gung Memorial Hospital, Linkou CMRPG3I0011Chang Gung Memorial Hospital, Linkou CMRPG3I0012Chang Gung Memorial Hospital, Linkou CMRPG3I0013
6 · The paper itself

Abstract

purposePerineural invasion (PNI) is an adverse prognostic factor in patients with oral cavity squamous cell carcinoma (OCSCC). The American Joint Committee on Cancer Staging Manual, eighth edition, introduced a subdivision of PNI into two distinct forms, that is, extratumoral and intratumoral PNI (EPNI and IPNI, respectively). We designed the current study to assess whether EPNI and IPNI have different prognostic implications in terms of disease control and survival outcomes in patients with OCSCC. MATERIALS AND

methodsWe retrospectively examined 229 consecutive patients with OCSCC and PNI who underwent radical surgery between July 2003 and November 2016. EPNI and IPNI were identified in 76 and 153 patients, respectively. The 5-year locoregional control (LRC), distant metastasis, disease-free survival (DFS), and overall survival (OS) rates served as the main outcome measures.

resultsCompared with patients showing IPNI, those with EPNI had a higher prevalence of worst pattern of invasion type-5 (P < 0.001), alcohol consumption (P = 0.03), and close margins (P = 0.002). Univariate analysis revealed that EPNI was a significant predictor of 5-year LRC (P = 0.024), DFS (P = 0.007), and OS (P = 0.034) rates. After allowance for potential confounders in multivariable analysis, ENPI was retained in the model as an independent predictor of 5-year LRC (P = 0.028), DFS (P = 0.011), and OS (P = 0.034) rates.

conclusionCompared with IPNI, the presence of EPNI in OCSCC portends less favorable outcomes. Patients with EPNI are potential candidates for definite aggressive treatment modalities aimed at improving prognosis.

Indexed as

AdultAgedAged, 80 and overCarcinoma, Squamous CellCombined Modality TherapyFemaleHumansMaleMiddle AgedMouth NeoplasmsNeoplasm InvasivenessNeoplasm MetastasisNeoplasm StagingPeripheral NervesPrognosisRetrospective Studiesdisease controloral cavity squamous cell carcinomaperineural invasionprognosissurvival outcomes

Identifiers

PMID31290283
PMCPMC6797567
OpenAlexW2960787469

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.