Evidence map›Paper›PMID 31290065›Full record

ArticleVirus genes2019

BetaHPV E6 and E7 colocalize with NuMa in dividing keratinocytes.

Evelyn Oswald, Matthias Kirschberg, François Aubin, Angel Alonso, Martin Hufbauer, Baki Akgül, Eeva Auvinen

Open access · greenAbstract read
PubMed Publisher
In one paragraph

Article in Virus genes, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 3 countries.

Evelyn OswaldGerman Cancer Research Center, Heidelberg, Germany.
Matthias KirschbergInstitute of Virology, University of Cologne, Faculty of Medicine and University Hospital of Cologne, Fürst-Pückler-Str.56, 50935, Cologne, Germany.
François AubinDepartment of Dermatology, Université de Franche-Comté, Besançon, France.
Angel AlonsoGerman Cancer Research Center, Heidelberg, Germany.
Martin HufbauerInstitute of Virology, University of Cologne, Faculty of Medicine and University Hospital of Cologne, Fürst-Pückler-Str.56, 50935, Cologne, Germany.
Baki AkgülInstitute of Virology, University of Cologne, Faculty of Medicine and University Hospital of Cologne, Fürst-Pückler-Str.56, 50935, Cologne, Germany. baki.akguel@uk-koeln.de.ORCID http://orcid.org/0000-0002-6564-9412
Eeva AuvinenUniversity of Helsinki and Helsinki University Hospital Laboratory, Helsinki, Finland.
University of Cologne · DEGerman Cancer Research Center · DEUniversité de franche-comté · FRUniversity of Helsinki · FI

Funding

Deutsche Krebshilfe (DE) 70112727Wilhelm Sander-Stiftung 2012.105.3
6 · The paper itself

Abstract

Human papillomaviruses (HPVs) of genus betapapillomavirus (betaHPV) are implicated in skin carcinogenesis, but their exact role in keratinocyte transformation is poorly understood. We show an interaction of HPV5 and HPV8 oncoproteins E6 and E7 with the nuclear mitotic apparatus protein 1 (NuMA). Binding of E6 or E7 to NuMA induces little aneuploidy, cell cycle alterations, or aberrant centrosomes. Intracellular localization of NuMA is not altered by E6 and E7 expression in 2D cultures. However, the localization profile is predominantly cytoplasmic in 3D organotypic skin models. Both viral proteins colocalize with NuMA in interphase cells, while only E7 colocalizes with NuMA in mitotic cells. Intriguingly, a small subset of cells shows E7 at only one spindle pole, whereas NuMA is present at both poles. This dissimilar distribution of E7 at the spindle poles may alter cell differentiation, which may in turn be relevant for betaHPV-induced skin carcinogenesis.

Indexed as

Host-Pathogen InteractionsBetapapillomavirusCell Cycle ProteinsHumansKeratinocytesOncogene Proteins, ViralPapillomavirus E7 ProteinsProtein BindingProtein Interaction MappingCell Cycle ProteinsE6 protein, human papillomavirus type 5E6 protein, Human papillomavirus type 8NUMA1 protein, humanOncogene Proteins, ViralPapillomavirus E7 ProteinsBetapapillomavirusE6E7 oncoproteinsHuman papillomavirusNuclear mitotic apparatus protein 1

Identifiers

PMID31290065
OpenAlexW2959155036

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.