Trial reportInternational urology and nephrology2019
Development and validation of prognostic nomograms for patients with metastatic prostate cancer.
Trial report in International urology and nephrology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed.
- Article
- Construction and validation of web-based nomograms for detecting and prognosticating in prostate adenocarcinoma with bone metastasis.Scientific reports · 2022Article
- Construction and validation of a novel prognostic nomogram for patients with metastatic renal cell carcinoma: a SEER-based study.The Journal of international medical research · 2022Article
- Bone marrow involvement in patients with metastatic castration sensitive prostate cancer.PloS one · 2022Article
- Nomograms predict survival benefits of radical prostatectomy and chemotherapy for prostate cancer with bone metastases: A SEER-based study.Frontiers in oncology · 2022Article
- Clinical characteristics and overall survival nomogram of second primary malignancies after prostate cancer, a SEER population-based study.Scientific reports · 2021Article
- Establishment and validation of a novel predictive model to quantify the risk of bone metastasis in patients with prostate cancer.Translational andrology and urology · 2021Article
- Nomograms for predicting long-term overall survival and cancer-specific survival in patients with primary urethral carcinoma: a population-based study.International urology and nephrology · 2020Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study aimed to develop and validate nomograms to predict overall survival (OS) and cancer-specific survival (CSS) in patients with prostate cancer.
methodsClinical data of patients with mPCa between 2010 and 2014 were retrieved retrospectively, and randomized into training (2/3) and validation sets (1/3). Nomograms were built with potential risk factors based on COX regression analysis. Accuracy was validated using the discrimination and calibration curve for the training and validation groups, respectively.
results6659 mPCa patients were collected and enrolled, including 4440 in the training set and 2219 in the validation set. Multivariate analysis showed that age, marital status, PSA, biopsy Gleason score, T stage, and bone metastasis were independent risk factors for both OS and CSS. The concordance index (C-index) of OS was 0.735 (95% CI 0.722-0.748) for the internal validation and 0.735 (95% CI 0.717-0.753) for the external validation. For CSS, it was 0.734 (95% CI 0.721-0.747) and 0.742 (95% CI 0.723-0.761), respectively. The nomograms for predicting OS and CSS displayed better discrimination power in both training and validation sets. Moreover, a favorable consistency between the predicted and actual survival probabilities was demonstrated using calibration curves.
conclusionsThe nomograms showed good performances for predicting OS and CSS in patients with prostate cancer. It might be a convenient individualized predictive tool for prognosis in clinical practice.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.