ArticleExperimental brain research2019
Neurophysiological mechanisms underlying motor skill learning in young and older adults.
Article in Experimental brain research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Corticospinal and spinal adaptations following lower limb motor skill training: a meta-analysis with best evidence synthesis.Experimental brain research · 2023Pooled it
- Tracking the corticospinal responses to strength training.European journal of applied physiology · 2020Trial
- Increased corticospinal excitability after rest with short term motor performance.Experimental physiology · 2026Article
- Motor cortex rTMS modulates adult ocular dominance plasticity.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- Modulation of primary motor cortex after experimentally induced and use-dependent plasticity in young and older adults.Experimental brain research · 2025Article
- The Influence of Transcranial Alternating Current Stimulation on the Excitability of the Unstimulated Contralateral Primary Motor Cortex.Brain sciences · 2025Article
- Intermittent hypoxia-induced enhancements in corticospinal excitability predict gains in motor learning and metabolic efficiency.Scientific reports · 2025Article
- Corticospinal and spinal responses following a single session of lower limb motor skill and resistance training.European journal of applied physiology · 2024Article
- Exploring the Influence of Inter-Trial Interval on the Assessment of Short-Interval Intracortical Inhibition.Bioengineering (Basel, Switzerland) · 2024Article
- Intermittent Hypoxia-Induced Enhancements in Corticospinal Excitability Predict Gains in Motor Learning and Metabolic Efficiency.Research square · 2024Article
- GABA, Aging and Exercise: Functional and Intervention Considerations.Neuroscience insights · 2024Review
- Repetitive paired-pulse TMS increases motor cortex excitability and visuomotor skill acquisition in young and older adults.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Intracortical facilitation and inhibition in human primary motor cortex during motor skill acquisition.Experimental brain research · 2022Article
- Age-related strengthening of cerebello-cortical motor circuits.Neurobiology of aging · 2022Article
- Anodal Transcranial Direct Current Stimulation Over Prefrontal Cortex Slows Sequence Learning in Older Adults.Frontiers in human neuroscience · 2022Article
- Motor cortex plasticity and visuomotor skill learning in upper and lower limbs of endurance-trained cyclists.European journal of applied physiology · 2022Article
- Physical activity, motor performance and skill learning: a focus on primary motor cortex in healthy aging.Experimental brain research · 2021Review
- Training at asymptote stabilizes motor memories by reducing intracortical excitation.Cortex; a journal devoted to the study of the nervous system and behavior · 2021Article
- Age-related changes in motor cortex plasticity assessed with non-invasive brain stimulation: an update and new perspectives.Experimental brain research · 2021Review
- Timing-specific effects of single-session M1 anodal tDCS on motor sequence retention in healthy older adults.Neuroimage. Reports · 2021Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The ability to acquire and retain novel motor skills is preserved with advancing age. However, the neurophysiological mechanisms underlying skill acquisition in older adults have received little systematic investigation. The aim of the present study was to assess the modulation of primary motor cortex excitability and inhibition after skill acquisition in young and older adults. Sixteen young and sixteen older adults trained on a sequential visual isometric wrist extension task. Anodal or sham transcranial direct current stimulation was applied during training in a pseudorandomized crossover design. Skill was quantified before, immediately after, 24 h and 7 days post-training. Transcranial magnetic stimulation protocols were used to examine corticomotor excitability and intracortical inhibition pre- and post-training. Corticomotor excitability increased and intracortical inhibition decreased after skill acquisition in both age groups. Anodal transcranial direct current stimulation did not enhance skill acquisition or the modulation of neurophysiological variables. These findings indicate potential neurophysiological mechanisms relevant for motor learning in neurorehabilitation contexts involving older adults, such as after stroke.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.