ArticleScience robotics2017
Additive manufacturing of hydrogel-based materials for next-generation implantable medical devices.
Article in Science robotics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed.
- Soft Ionic and Electronic Triboelectric Nanogenerators: Toward Attachable and Implantable Biomedical Applications.Advanced materials (Deerfield Beach, Fla.) · 2026Review
- Hydrogel Microspheres for Biomedical Applications.Small science · 2026Review
- TriMag Microrobots: 3D-Printed Microrobots for Magnetic Actuation, Imaging, and Hyperthermia.Advanced materials (Deerfield Beach, Fla.) · 2025Article
- Real-time in-situ ultrasound monitoring of soft hydrogel 3D printing with subwavelength resolution.Communications engineering · 2024Article
- Magnetomechanical Behaviors of Hard-Magnetic Elastomer Membranes Placed in Uniform Magnetic Field.Materials (Basel, Switzerland) · 2024Article
- Ultrasoft Long-Lasting Reusable Hydrogel-Based Sensor Patch for Biosignal Recording.Biosensors · 2024Article
- Unconventional acoustic wave propagation transitions induced by resonant scatterers in the high-density limit.Scientific reports · 2024Article
- Local dose-dense chemotherapy for triple-negative breast cancer via minimally invasive implantation of 3D printed devices.Asian journal of pharmaceutical sciences · 2024Article
- Self-powered, light-controlled, bioresorbable platforms for programmed drug delivery.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Emerging Magnetic Fabrication Technologies Provide Controllable Hierarchically-Structured Biomaterials and Stimulus Response for Biomedical Applications.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Review
- New Materials Based on Polyvinylpyrrolidone-Containing Copolymers with Ferromagnetic Fillers.Materials (Basel, Switzerland) · 2022Article
- A Heating-Assisted Direct Ink Writing Method for Preparation of PDMS Cellular Structure with High Manufacturing Fidelity.Polymers · 2022Article
- Recent Progress in Materials Chemistry to Advance Flexible Bioelectronics in Medicine.Advanced materials (Deerfield Beach, Fla.) · 2022Review
- Continuous Three-Dimensional Printing of Architected Piezoelectric Sensors in Minutes.Research (Washington, D.C.) · 2022Article
- Crystallization of the Multi-Receptor Tyrosine Kinase Inhibitor Sorafenib for Controlled Long-Term Drug Delivery Following a Single Injection.Cellular and molecular bioengineering · 2021Article
- Thermo-Responsive Hydrogel-Based Soft Valves with Annular Actuation Calibration and Circumferential Gripping.Bioengineering (Basel, Switzerland) · 2021Article
- Recent progress of biomimetic motions-from microscopic micro/nanomotors to macroscopic actuators and soft robotics.RSC advances · 2021Review
- 3D Printing Hydrogel-Based Soft and Biohybrid Actuators: A Mini-Review on Fabrication Techniques, Applications, and Challenges.Frontiers in robotics and AI · 2021Review
- Addressable Acoustic Actuation of 3D Printed Soft Robotic Microsystems.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2020Article
- Biohybrid Design Gets Personal: New Materials for Patient-Specific Therapy.Advanced materials (Deerfield Beach, Fla.) · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
Implantable microdevices often have static components rather than moving parts, and exhibit limited biocompatibility. This paper demonstrates a fast manufacturing method which can produce features in biocompatible materials down to tens of microns in scale, with intricate and composite patterns in each layer. By exploiting unique mechanical properties of hydrogels, we developed a "locking mechanism" for precise actuation and movement of freely moving parts, which can provide functions such as valves, manifolds, rotors, pumps, and delivery of payloads. Hydrogel components could be tuned within a wide range of mechanical and diffusive properties, and can be controlled after implantation without a sustained power supply. In a mouse model of osteosarcoma, triggering of release of doxorubicin from the device over ten days showed high treatment efficacy and low toxicity, at one-tenth of a standard systemic chemotherapy dose. Overall, this platform, called "iMEMS", enables development of biocompatible implantable microdevices with a wide range of intricate moving components that can be wirelessly controlled on demand, in a manner that solves issues of device powering and biocompatibility.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.