ArticleFood science & nutrition2019
Capability of polygonum cuspidatum extract in inhibiting AGEs and preventing diabetes.
Article in Food science & nutrition, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- The Invasive SpeciesFrontiers in pharmacology · 2022Pooled it
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- Binding of β-lactoglobulin to three phenolics improves the stability of phenolics studied by multispectral analysis and molecular modeling.Food chemistry: X · 2022Article
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- Identification of Molecular Targets and Underlying Mechanisms of Xiaoji Recipe against Pancreatic Cancer Based on Network Pharmacology.Computational and mathematical methods in medicine · 2022Article
- Antiglycoxidative Properties of Extracts and Fractions fromNutrients · 2021Article
- Phytochemicals against anti-diabetic complications: targeting the advanced glycation end product signaling pathway.Archives of pharmacal research · 2021Review
- The hepatoprotective effects of fennel seeds extract andFood science & nutrition · 2021Article
- Investigation of the Active Ingredients and Mechanism ofDrug design, development and therapy · 2021Article
- Capability of polygonum cuspidatum extract in inhibiting AGEs and preventing diabetes.Food science & nutrition · 2019Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diabetes is a metabolic disorder disease associated with advanced glycation end products (AGEs) and protein glycation. The effect of polygonum cuspidatum extract (PE) on AGEs and Nε-(Carboxymethyl)-L-lysine formation, protein glycation, and diabetes was investigated. Six primary phenolics in a range of 12.36 mg/g for ellagic acid to 0.01 mg/g for piceid were determined in PE. In an intermediate-moisture-foods model, inhibition rate of PE was as high as 54.2% for AGEs and 78.9% for CML under aw 0.75. The protein glycation was also inhibited by PE. In a diabetic rat model, the levels of blood glucose, serum malondialdehyde, cholesterol, triglycerides, and low-density lipoproteins were effectively reduced by PE treatment. The antioxidation capacity (T-AOC) and superoxide dismutase (SOD) activity were also mediated by PE. Additionally, the activates of liver function-related enzymes including alkaline phosphatase (ALP), glutamate pyruvate transaminase (GPT), and glutamate oxaloacetate transaminase (GOT) in diabetic rat were improved by PE.
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